ArticleAmerican journal of physiology. Lung cellular and molecular physiology2022
Carbonic anhydrase and soluble adenylate cyclase regulation of cystic fibrosis cellular phenotypes.
Article in American journal of physiology. Lung cellular and molecular physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
5 citing papers in PubMed, 9 citations in OpenAlex.
- HDAC6 inhibition reducesInfection and immunity · 2026Article
- 6-Methylsulfinylhexyl isothiocyanate activates carbonic anhydrase-dependent HCOThe Journal of physiology · 2026Article
- New isoxazolidinyl-basedJournal of enzyme inhibition and medicinal chemistry · 2023Article
- A unique presentation of hyponatremia and seizures in a 2-month-old child with cystic fibrosis: a case report.Annals of medicine and surgery (2012) · 2023Article
- New Histamine-Related Five-Membered N-Heterocycle Derivatives as Carbonic Anhydrase I Activators.Molecules (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Several aspects of the cell biology of cystic fibrosis (CF) epithelial cells are altered including impaired lipid regulation, disrupted intracellular transport, and impaired microtubule regulation. It is unclear how the loss of cystic fibrosis transmembrane conductance regulator (CFTR) function leads to these differences. It is hypothesized that the loss of CFTR function leads to altered regulation of carbonic anhydrase (CA) activity resulting in cellular phenotypic changes. In this study, it is demonstrated that CA2 protein expression is reduced in CF model cells, primary mouse nasal epithelial (MNE) cells, excised MNE tissue, and primary human nasal epithelial cells (
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