Evidence map›Paper›PMID 34986316›Full record

ArticlemSphere2022

The Protective Role of 1,8-Dihydroxynaphthalene-Melanin on Conidia of the Opportunistic Human Pathogen Aspergillus fumigatus Revisited: No Role in Protection against Hydrogen Peroxide and Superoxides.

E M Keizer, I D Valdes, B L McCann, E M Bignell, H A B Wösten, H de Cock

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. A roadmap to chemically reactive species: how diverse oxidants affectMicrobiology and molecular biology reviews : MMBR · 2025
    Review
  2. Article
  3. Antifungal Innate Immunity.Advances in experimental medicine and biology · 2025
    Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

E M KeizerMicrobiology, Department of Biology, Utrecht Universitygrid.5477.1, Utrecht, the Netherlands.
I D ValdesMicrobiology, Department of Biology, Utrecht Universitygrid.5477.1, Utrecht, the Netherlands.
B L McCannMRC Centre for Medical Mycology, University of Exeter, Exerter, United Kingdom.
E M BignellMRC Centre for Medical Mycology, University of Exeter, Exerter, United Kingdom.
H A B WöstenMicrobiology, Department of Biology, Utrecht Universitygrid.5477.1, Utrecht, the Netherlands.
H de CockMicrobiology, Department of Biology, Utrecht Universitygrid.5477.1, Utrecht, the Netherlands.ORCID 0000-0002-8420-6764
Utrecht University · NLUniversity of Exeter · GB

Funding

Medical Research Council MR/N006364/2Medical Research Council MR/S001824/1Medical Research Council MR/S001824/2Medical Research Council MR/V033417/1
6 · The paper itself

Abstract

Previously, 1,8-dihydroxynaphthalene (DHN)-melanin was described to protect Aspergillus fumigatus against hydrogen peroxide (H

Indexed as

Aspergillus fumigatusSuperoxidesHumansHydrogen PeroxideMelaninsNaphtholsReactive Oxygen SpeciesSpores, Fungal1,8-dihydroxynaphthaleneHydrogen PeroxideMelaninsNaphtholsReactive Oxygen SpeciesSuperoxidesAspergillus fumigatuscatalaseconidiaDHN-melaninhydrogen peroxidereactive oxygen species

Identifiers

PMID34986316
PMCPMC8730813
OpenAlexW4205482067

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.