Evidence map›Paper›PMID 34986315›Full record

ArticlemSphere2022

Human Milk Oligosaccharides Reduce Murine Group B

Marlyd E Mejia, Samantha Ottinger, Alison Vrbanac, Priyanka Babu, Jacob J Zulk, David Moorshead, Lars Bode, Victor Nizet, Kathryn A Patras

Open access · goldAbstract read
In one paragraph

Article in mSphere, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. 2'-Fucosyllactose AttenuatesMicroorganisms · 2026
    Article
  4. Review
  5. Type 2 diabetes mellitus exacerbates vaginal group BbioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Review
  8. Influence of cervicovaginal microbiota onMicrobial cell (Graz, Austria) · 2025
    Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Marlyd E MejiaDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Samantha OttingerDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Alison VrbanacDepartment of Pediatrics, UC San Diego, La Jolla, California, USA.
Priyanka BabuDepartment of Pediatrics, UC San Diego, La Jolla, California, USA.
Jacob J ZulkDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
David MoorsheadDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.
Lars BodeDepartment of Pediatrics, UC San Diego, La Jolla, California, USA.
Victor NizetDepartment of Pediatrics, UC San Diego, La Jolla, California, USA.
Kathryn A PatrasDepartment of Molecular Virology and Microbiology, Baylor College of Medicinegrid.39382.33, Houston, Texas, USA.ORCID 0000-0003-2631-8810
Baylor College of Medicine · USUniversity of California San Diego · US

Funding

The Clinical Translational Research Certificate of Added Qualification ProgramT32GM136554 · NIGMS · BAYLOR COLLEGE OF MEDICINE · PI Melissa Suter, IGNATIA B VAN DEN VEYVER · 2020 to 2026
$3.0M
NIGMS NIH HHS T32 GM136554
6 · The paper itself

Abstract

Group B Streptococcus (GBS) colonizes the vaginal mucosa of a significant percentage of healthy women and is a leading cause of neonatal bacterial infections. Currently, pregnant women are screened in the last month of pregnancy, and GBS-positive women are given antibiotics during parturition to prevent bacterial transmission to the neonate. Recently, human milk oligosaccharides (HMOs) isolated from breastmilk were found to inhibit GBS growth and biofilm formation

Indexed as

MicrobiotaPremature BirthAnimalsAnti-Bacterial AgentsBacteriaFemaleHumansInfant, NewbornMiceMilk, HumanOligosaccharidesPregnancyRNA, Ribosomal, 16SStreptococcus agalactiaeAnti-Bacterial AgentsOligosaccharidesRNA, Ribosomal, 16Santimicrobial activitygroup B Streptococcushuman milk oligosaccharidesvaginal colonizationvaginal microbiota

Identifiers

PMID34986315
PMCPMC8730812
OpenAlexW4221061834

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.