Evidence map›Paper›PMID 34986255›Full record

ReviewDiabetes care2022

The Noble and Often Nobel Role Played by Insulin-Focused Research in Modern Medicine.

Victor S Harrison, Mahfuzul H Khan, Christine E Chamberlain, David M Harlan

Open access · bronzeAbstract readHistorical ArticleReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Diabetes care, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Victor S Harrison1Southeast Alaska Regional Health Consortium (SEARHC), Wrangell, AK.
Mahfuzul H Khan2Carroll Health Group, Westminster, MD.
Christine E Chamberlain3Division of Pharmacovigilance, Office of Surveillance and Epidemiology, U.S. Food and Drug Administration, Silver Spring, MD.
David M Harlan4Diabetes Center of Excellence, Department of Medicine, UMass Chan School of Medicine, Worcester, MA.ORCID 0000-0002-6938-8109
Southeast Alaska Regional Health Consortium · USUnited States Food and Drug Administration · USUniversity of Massachusetts Chan Medical School · US

Funding

Humanized Mouse Avatars for T1DU01DK104218 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BREHM, MICHAEL ALLEN, GREINER, DALE LESLIE · 2019 to 2023
$4.5M
Human Islet-Infiltrating T Cell Biology: Reactivity, Structure, and FunctionUC4DK116284 · NIDDK · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI HARLAN, DAVID MARSHALL, KENT, SALLY CHOATE · 2017 to 2017
$2.0M
NIDDK NIH HHS U01 DK104218NIDDK NIH HHS UC4 DK116284
6 · The paper itself

Abstract

Since diabetes was first described over 3,000 years ago, clinicians and scientists alike have sought ever improving treatments en route to a cure. As we approach the 100th anniversary of insulin's first therapeutic use, this article will recount the glorious history associated with research surrounding insulin's isolation, purification, cloning, and subsequent modification. The discovery path we will relate tells the story of many relentless and passionate investigators pursuing ground-breaking research. The fruits of their labor include several Nobel Prizes, new technology, and, more importantly, ever improving treatments for one of humankind's greatest medical scourges.

Indexed as

Diabetes MellitusInsulinHistory, 20th CenturyHumansInsulin, Regular, HumanNobel PrizeResearch PersonnelInsulinInsulin, Regular, Human

Identifiers

PMID34986255
PMCPMC9004313
OpenAlexW4206611777

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.