Evidence map›Paper›PMID 34986191›Full record

ArticlePloS one

Coupled exoskeleton assistance simplifies control and maintains metabolic benefits: A simulation study.

Nicholas A Bianco, Patrick W Franks, Jennifer L Hicks, Scott L Delp

Open access · greenAbstract read
In one paragraph

Article in PloS one. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Biomechanical models in the lower-limb exoskeletons development: a review.Journal of neuroengineering and rehabilitation · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Nicholas A BiancoDepartment of Mechanical Engineering, Stanford University, Stanford, California, United States of America.ORCID https://orcid.org/0000-0003-2229-4065
Patrick W FranksDepartment of Mechanical Engineering, Stanford University, Stanford, California, United States of America.
Jennifer L HicksDepartment of Bioengineering, Stanford University, Stanford, California, United States of America.
Scott L DelpDepartment of Mechanical Engineering, Stanford University, Stanford, California, United States of America.
Stanford University · USBioengineering Center · RU

Funding

Training CoreU54EB020405 · NIBIB · STANFORD UNIVERSITY · PI DELP, SCOTT L · 2014 to 2018
$11.6M
TR&D Project 3: OpenSim for PredictionP41EB027060 · NIBIB · STANFORD UNIVERSITY · PI SCOTT L DELP · 2020 to 2026
$9.7M
Tech-DevelopmentP2CHD065690 · NICHD · STANFORD UNIVERSITY · PI DELP, SCOTT L · 2015 to 2019
$5.4M
Technology DevelopmentP2CHD101913 · NICHD · STANFORD UNIVERSITY · PI DELP, SCOTT L · 2020 to 2024
$4.1M
NIBIB NIH HHS P41 EB027060NIBIB NIH HHS U54 EB020405NICHD NIH HHS P2C HD065690NICHD NIH HHS P2C HD101913
6 · The paper itself

Abstract

Assistive exoskeletons can reduce the metabolic cost of walking, and recent advances in exoskeleton device design and control have resulted in large metabolic savings. Most exoskeleton devices provide assistance at either the ankle or hip. Exoskeletons that assist multiple joints have the potential to provide greater metabolic savings, but can require many actuators and complicated controllers, making it difficult to design effective assistance. Coupled assistance, when two or more joints are assisted using one actuator or control signal, could reduce control dimensionality while retaining metabolic benefits. However, it is unknown which combinations of assisted joints are most promising and if there are negative consequences associated with coupled assistance. Since designing assistance with human experiments is expensive and time-consuming, we used musculoskeletal simulation to evaluate metabolic savings from multi-joint assistance and identify promising joint combinations. We generated 2D muscle-driven simulations of walking while simultaneously optimizing control strategies for simulated lower-limb exoskeleton assistive devices to minimize metabolic cost. Each device provided assistance either at a single joint or at multiple joints using massless, ideal actuators. To assess if control could be simplified for multi-joint exoskeletons, we simulated different control strategies in which the torque provided at each joint was either controlled independently or coupled between joints. We compared the predicted optimal torque profiles and changes in muscle and total metabolic power consumption across the single joint and multi-joint assistance strategies. We found multi-joint devices-whether independent or coupled-provided 50% greater metabolic savings than single joint devices. The coupled multi-joint devices were able to achieve most of the metabolic savings produced by independently-controlled multi-joint devices. Our results indicate that device designers could simplify multi-joint exoskeleton designs by reducing the number of torque control parameters through coupling, while still maintaining large reductions in metabolic cost.

Indexed as

AdultAnimalsAnkleAnkle JointBiomechanical PhenomenaComputer SimulationElectromyographyEnergy MetabolismExoskeleton DeviceHumansMaleMuscle, SkeletalSelf-Help DevicesWalking

Identifiers

PMID34986191
PMCPMC8730392
OpenAlexW3154947154

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.