Evidence map›Paper›PMID 34986162›Full record

ArticlePloS one2022

Dry heat sterilization as a method to recycle N95 respirator masks: The importance of fit.

John G Yuen, Amy C Marshilok, Peter Todd Benziger, Shan Yan, Jeronimo Cello, Chavis A Stackhouse, Kim Kisslinger, David C Bock, Esther S Takeuchi, Kenneth J Takeuchi and 6 more

Open access · goldAbstract read
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Modifying NIOSH's Manikin Fit Evaluation Method to Match Fit Testing with Human Subjects.Journal of the International Society for Respiratory Protection · 2023
    Article
  6. Article
  7. Brief Cost Analysis of Surgical Personal Protective Equipment During the COVID-19 Pandemic.Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

John G YuenDepartment of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, United States of America.ORCID 0000-0002-1569-3298
Amy C MarshilokInterdisciplinary Science Department, Brookhaven National Laboratory, Upton, New York, United States of America.ORCID 0000-0001-9174-0474
Peter Todd BenzigerDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, United States of America.
Shan YanInterdisciplinary Science Department, Brookhaven National Laboratory, Upton, New York, United States of America.
Jeronimo CelloDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, United States of America.
Chavis A StackhouseInstitute for Electrochemically Stored Energy, Stony Brook University, Stony Brook, New York, United States of America.ORCID 0000-0002-3773-5321
Kim KisslingerCenter for Functional Nanomaterials, Brookhaven National Laboratory, Upton, New York, United States of America.
David C BockInterdisciplinary Science Department, Brookhaven National Laboratory, Upton, New York, United States of America.
Esther S TakeuchiInterdisciplinary Science Department, Brookhaven National Laboratory, Upton, New York, United States of America.
Kenneth J TakeuchiInterdisciplinary Science Department, Brookhaven National Laboratory, Upton, New York, United States of America.
Lei WangInterdisciplinary Science Department, Brookhaven National Laboratory, Upton, New York, United States of America.
Sruthi BabuDepartment of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, United States of America.
Glen ItzkowitzOffice of the Dean, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, United States of America.
David ThanassiDepartment of Microbiology and Immunology, Stony Brook University, Stony Brook, New York, United States of America.
Daniel A KnopfSchool of Marine and Atmospheric Sciences, Stony Brook University, Stony Brook, New York, United States of America.ORCID 0000-0001-7732-3922
Kenneth R ShroyerDepartment of Pathology, Renaissance School of Medicine, Stony Brook University, Stony Brook, New York, United States of America.
Brookhaven National Laboratory · USStony Brook University · USStony Brook School · US

Funding

IRACDA - The New York Consortium for the Advancement of Postdoctoral Scholars (NY CAPS)Phase IIK12GM102778 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI Carol A. Carter, Karian Janice Wright · 2012 to 2026
$13.1M
MEDICAL SCIENTIST TRAINING PROGRAMT32GM008444 · NIGMS · STATE UNIVERSITY NEW YORK STONY BROOK · PI FROHMAN, MICHAEL A. · 1992 to 2024
$12.6M
MOLECULAR AND CELL BIOLOGY OF INFECTIOUS DISEASEST32AI007539 · NIAID · STATE UNIVERSITY NEW YORK STONY BROOK · PI KONOPKA, JAMES B · 1998 to 2023
$3.6M
NIAID NIH HHS T32 AI007539NIGMS NIH HHS K12 GM102778NIGMS NIH HHS T32 GM008444
6 · The paper itself

Abstract

In times of crisis, including the current COVID-19 pandemic, the supply chain of filtering facepiece respirators, such as N95 respirators, are disrupted. To combat shortages of N95 respirators, many institutions were forced to decontaminate and reuse respirators. While several reports have evaluated the impact on filtration as a measurement of preservation of respirator function after decontamination, the equally important fact of maintaining proper fit to the users' face has been understudied. In the current study, we demonstrate the complete inactivation of SARS-CoV-2 and preservation of fit test performance of N95 respirators following treatment with dry heat. We apply scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM/EDS), X-ray diffraction (XRD) measurements, Raman spectroscopy, and contact angle measurements to analyze filter material changes as a consequence of different decontamination treatments. We further compared the integrity of the respirator after autoclaving versus dry heat treatment via quantitative fit testing and found that autoclaving, but not dry heat, causes the fit of the respirator onto the users face to fail, thereby rendering the decontaminated respirator unusable. Our findings highlight the importance to account for both efficacy of disinfection and mask fit when reprocessing respirators to for clinical redeployment.

Indexed as

Equipment ReuseCOVID-19DecontaminationEquipment and SuppliesHealth PersonnelHot TemperatureHumansN95 RespiratorsPandemicsSARS-CoV-2

Identifiers

PMID34986162
PMCPMC8730429
OpenAlexW4225666904

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.