Evidence map›Paper›PMID 34985954›Full record

ArticleScience advances2022

Wearable aptamer-field-effect transistor sensing system for noninvasive cortisol monitoring.

Bo Wang, Chuanzhen Zhao, Zhaoqing Wang, Kyung-Ae Yang, Xuanbing Cheng, Wenfei Liu, Wenzhuo Yu, Shuyu Lin, Yichao Zhao, Kevin M Cheung and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 140 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
140citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

140 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  4. Engineering two-dimensional electronic biosensors.Nature reviews electrical engineering · 2026
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80 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Bo WangInterconnected and Integrated Bioelectronics Lab (I2BL), Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-3986-3415
Chuanzhen ZhaoDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-0162-1231
Zhaoqing WangInterconnected and Integrated Bioelectronics Lab (IBL), Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-5548-3965
Kyung-Ae YangDivision of Experimental Therapeutics, Department of Medicine, Columbia University, New York, NY 10032, USA.ORCID 0000-0001-5575-4107
Xuanbing ChengInterconnected and Integrated Bioelectronics Lab (IBL), Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-7682-0759
Wenfei LiuDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-1338-7905
Wenzhuo YuInterconnected and Integrated Bioelectronics Lab (IBL), Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-1904-9088
Shuyu LinInterconnected and Integrated Bioelectronics Lab (IBL), Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-5248-6124
Yichao ZhaoInterconnected and Integrated Bioelectronics Lab (IBL), Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-2884-8105
Kevin M CheungDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-1586-0364
Haisong LinInterconnected and Integrated Bioelectronics Lab (IBL), Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-5684-6385
Hannaneh HojaijiInterconnected and Integrated Bioelectronics Lab (IBL), Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-1963-5458
Paul S WeissDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0001-5527-6248
Milan N StojanovićDivision of Experimental Therapeutics, Department of Medicine, Columbia University, New York, NY 10032, USA.ORCID 0000-0001-6340-0982
A Janet TomiyamaDepartment of Psychology, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-2152-5813
Anne M AndrewsDepartment of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0002-1961-4833
Sam EmaminejadInterconnected and Integrated Bioelectronics Lab (IBL), Department of Electrical and Computer Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.ORCID 0000-0003-0132-152X

Funding

Micro- to Nanoscale Neurochemical SensorsR01DA045550 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ANDREWS, ANNE MILASINCIC · 2017 to 2021
$5.8M
Analog-based Approaches to Isolation of Aptamers for Challenging TargetsR01GM138843 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI STOJANOVIC, MILAN N · 2020 to 2023
$2.3M
NIDA NIH HHS R01 DA045550NIGMS NIH HHS R01 GM138843
6 · The paper itself

Abstract

Wearable technologies for personalized monitoring require sensors that track biomarkers often present at low levels. Cortisol—a key stress biomarker—is present in sweat at low nanomolar concentrations. Previous wearable sensing systems are limited to analytes in the micromolar-millimolar ranges. To overcome this and other limitations, we developed a flexible field-effect transistor (FET) biosensor array that exploits a previously unreported cortisol aptamer coupled to nanometer-thin-film In

Identifiers

PMID34985954
PMCPMC8730602

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.