Evidence map›Paper›PMID 34985933›Full record

ArticleMolecular biology of the cell2022

The transcriptional response to oxidative stress is independent of stress-granule formation.

Amanjot Singh, Arvind Reddy Kandi, Deepa Jayaprakashappa, Guillaume Thuery, Devam J Purohit, Joern Huelsmeier, Rashi Singh, Sai Shruti Pothapragada, Mani Ramaswami, Baskar Bakthavachalu

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Connecting the Dots: Stress Granule and Cardiovascular Diseases.Journal of cardiovascular translational research · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Amanjot SinghNational Centre for Biological Sciences, TIFR, Bangalore 560065, India.
Arvind Reddy KandiTata Institute for Genetics and Society Centre at inStem, Bellary Road, Bangalore 560065, India.
Deepa JayaprakashappaNational Centre for Biological Sciences, TIFR, Bangalore 560065, India.
Guillaume ThueryTrinity College Institute of Neuroscience, School of Genetics and Microbiology, Smurfit Institute of Genetics and School of Natural Sciences, Trinity College Dublin, Dublin-2, Ireland.
Devam J PurohitNational Centre for Biological Sciences, TIFR, Bangalore 560065, India.
Joern HuelsmeierTrinity College Institute of Neuroscience, School of Genetics and Microbiology, Smurfit Institute of Genetics and School of Natural Sciences, Trinity College Dublin, Dublin-2, Ireland.
Rashi SinghNational Centre for Biological Sciences, TIFR, Bangalore 560065, India.
Sai Shruti PothapragadaNational Centre for Biological Sciences, TIFR, Bangalore 560065, India.
Mani RamaswamiNational Centre for Biological Sciences, TIFR, Bangalore 560065, India.
Baskar BakthavachaluTata Institute for Genetics and Society Centre at inStem, Bellary Road, Bangalore 560065, India.
National Centre for Biological Sciences · INTrinity College Dublin · IETata Institute for Genetics and Society · IN

Funding

DROSOPHILA GENOMICS RESOURCE CENTERP40OD010949 · OD · TRUSTEES OF INDIANA UNIVERSITY · PI Andrew Zelhof · 2012 to 2026
$9.4M
DBT-Wellcome Trust India Alliance IA/I/19/1/504286NIH HHS P40 OD010949Wellcome Trust
6 · The paper itself

Abstract

Cells respond to stress with translational arrest, robust transcriptional changes, and transcription-independent formation of mRNP assemblies termed stress granules (SGs). Despite considerable interest in the role of SGs in oxidative, unfolded protein and viral stress responses, whether and how SGs contribute to stress-induced transcription have not been rigorously examined. To address this, we characterized transcriptional changes in

Indexed as

DNA HelicasesRNA HelicasesCytoplasmic GranulesOxidative StressPoly-ADP-Ribose Binding ProteinsRNA Recognition Motif ProteinsStress, PhysiologicalDNA HelicasesPoly-ADP-Ribose Binding ProteinsRNA HelicasesRNA Recognition Motif Proteins

Identifiers

PMID34985933
PMCPMC9250384
OpenAlexW4226178628

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.