Evidence map›Paper›PMID 34985913›Full record

ArticleMolecular biology of the cell2022

Pannexin 2 is expressed in murine skin and promotes UVB-induced apoptosis of keratinocytes.

Rafael E Sanchez-Pupo, Brooke L O'Donnell, Danielle Johnston, Laszlo Gyenis, David W Litchfield, Silvia Penuela

Open access · greenAbstract read
In one paragraph

Article in Molecular biology of the cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Pannexins in the vasculature.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  3. Pannexin channels in the kidney.American journal of physiology. Renal physiology · 2025
    Review
  4. Review
  5. Pannexin channels in inflammation and tumorigenesis.Frontiers in cell and developmental biology · 2025
    Review
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Rafael E Sanchez-PupoDepartments of Anatomy and Cell Biology and.
Brooke L O'DonnellDepartments of Anatomy and Cell Biology and.
Danielle JohnstonDepartments of Anatomy and Cell Biology and.
Laszlo GyenisBiochemistry and.
David W LitchfieldBiochemistry and.
Silvia PenuelaDepartments of Anatomy and Cell Biology and.
Western University · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pannexins (PANX) are a family of three channel-forming membrane glycoproteins expressed in the skin. Previous studies have focused on the role of PANX1 and PANX3 in the regulation of cellular functions in skin cells while PANX2, the largest member of this protein family, has not been investigated. In the current study, we explored the temporal PANX2 expression in murine skin and found that one

Indexed as

Nerve Tissue ProteinsAnimalsApoptosisConnexinsKeratinocytesMiceProtein Processing, Post-TranslationalRatsUltraviolet RaysConnexinsNerve Tissue ProteinsPanx1 protein, mousePanx2 protein, mouse

Identifiers

PMID34985913
PMCPMC9250380
OpenAlexW4206608397

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.