Evidence map›Paper›PMID 34985880›Full record

ArticleJournal of the American Chemical Society2022

Evidence for a Long-Lived, Cu-Coupled and Oxygen-Inert Disulfide Radical Anion in the Assembly of Metallothionein-3 Cu(I)

Jenifer S Calvo, Rhiza Lyne E Villones, Nicholas J York, Ewelina Stefaniak, Grace E Hamilton, Allison L Stelling, Wojciech Bal, Brad S Pierce, Gabriele Meloni

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Pathogenic RBiochemistry · 2024
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jenifer S CalvoDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Road, Richardson, Texas 75080, United States.
Rhiza Lyne E VillonesDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Road, Richardson, Texas 75080, United States.
Nicholas J YorkDepartment of Chemistry and Biochemistry, University of Alabama, 250 Hackberry Lane, Tuscaloosa, Alabama 35401, United States.ORCID 0000-0001-7054-8336
Ewelina StefaniakInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5a, 02-106 Warsaw, Poland.
Grace E HamiltonDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Road, Richardson, Texas 75080, United States.
Allison L StellingDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Road, Richardson, Texas 75080, United States.ORCID 0000-0002-0368-0852
Wojciech BalInstitute of Biochemistry and Biophysics, Polish Academy of Sciences, Pawińskiego 5a, 02-106 Warsaw, Poland.ORCID 0000-0003-3780-083X
Brad S PierceDepartment of Chemistry and Biochemistry, University of Alabama, 250 Hackberry Lane, Tuscaloosa, Alabama 35401, United States.ORCID 0000-0002-7432-6332
Gabriele MeloniDepartment of Chemistry and Biochemistry, The University of Texas at Dallas, 800 W. Campbell Road, Richardson, Texas 75080, United States.ORCID 0000-0003-4976-1401

Funding

Principles of selectivity and translocation in transition metal transporters, metallochaperones, and associated metalloproteinsR35GM128704 · NIGMS · UNIVERSITY OF TEXAS DALLAS · PI Gabriele Meloni · 2018 to 2026
$3.5M
Pre-steady state kinetics and O2/NO-reactivity among thiol dioxygenase enzymesR15GM117511 · NIGMS · UNIVERSITY OF TEXAS ARLINGTON · PI PIERCE, BRADLEY S · 2015 to 2023
$1.2M
NIGMS NIH HHS R15 GM117511NIGMS NIH HHS R35 GM128704
6 · The paper itself

Abstract

The human copper-binding protein metallothionein-3 (MT-3) can reduce Cu(II) to Cu(I) and form a polynuclear Cu(I)

Indexed as

CopperDisulfidesElectron Spin Resonance SpectroscopyFree RadicalsGlutathioneHumansMetallothionein 3Oxidation-ReductionOxygenRecombinant ProteinsSpectrometry, FluorescenceZincCopperDisulfidesFree RadicalsGlutathioneMetallothionein 3OxygenRecombinant ProteinsZinc

Identifiers

PMID34985880
PMCPMC9029059

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.