Evidence map›Paper›PMID 34985846›Full record

ArticleTrends in psychiatry and psychotherapy

Combined effects of theta-burst stimulation with transcranial direct current stimulation of the prefrontal cortex: study protocol of a randomized, double-blinded, sham-controlled trial using 99mTc-ECD SPECT.

Laís B Razza, Carlos A Buchpiguel, Stefanie De Smet, Izio Klein, Chris Baeken, Ricardo Galhardoni, Marie-Anne Vanderhasselt, André R Brunoni

Open access · diamondAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trends in psychiatry and psychotherapy. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 3 countries.

Laís B RazzaServiço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento e Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Carlos A BuchpiguelDepartamento de Medicina Interna, Faculdade de Medicina, USP, São Paulo, SP, Brazil.
Stefanie De SmetDepartment of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, Ghent, Belgium. Ghent Experimental Psychiatry (GHEP) Lab, Ghent, Belgium.
Izio KleinServiço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento e Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil.
Chris BaekenDepartment of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, Ghent, Belgium. Ghent Experimental Psychiatry (GHEP) Lab, Ghent, Belgium. Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.
Ricardo GalhardoniEscola de Medicina, Universidade Cidade de São Paulo (UNICID), São Paulo, SP, Brazil. Centro de Dor, LIM-62, Departamento de Neurologia, USP, São Paulo, SP, Brazil.
Marie-Anne VanderhasseltDepartment of Head and Skin, Psychiatry and Medical Psychology, Ghent University Hospital, Ghent University, Ghent, Belgium. Ghent Experimental Psychiatry (GHEP) Lab, Ghent, Belgium. Department of Experimental Clinical and Health Psychology, Ghent University, Ghent, Belgium.
André R BrunoniServiço Interdisciplinar de Neuromodulação, Laboratório de Neurociências (LIM-27), Departamento e Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo, SP, Brazil. Departamento de Medicina Interna, Faculdade de Medicina, USP, São Paulo, SP, Brazil. Instituto Nacional de Biomarcadores em Neuropsiquiatria (INBioN), LIM-27, Departamento e Instituto de Psiquiatria, Faculdade de Medicina, USP, São Paulo, SP, Brazil. Hospital Universitário, USP, São Paulo, SP, Brazil.
Ghent University Hospital · BEHospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo · BRFundação Faculdade de Medicina · BRNational Biodiversity Institute · CRUniversidade Cidade de São Paulo · BR

Funding

Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/10861-7Research Foundation - Flanders G0F4619N
6 · The paper itself

Abstract

introductionNon-invasive brain stimulation (NIBS) as monotherapy has been increasingly used to enhance the activity of brain networks. However, it is unclear whether a combination of distinct NIBS approaches could enhance prefrontal cortical (PFC) activity.

objectiveWe propose to investigate the combined and standalone effects of two NIBS modalities on the PFC through a working memory task, single photon emission computed tomography (SPECT), and salivary cortisol. We hypothesize that the combined protocol will provoke greater changes in the collected measures compared to the remining protocols.

methodsA randomized, double-blind, sham-controlled, full-factorial design will be conducted. The effects of transcranial direct current stimulation (tDCS) and intermittent theta-burst stimulation (iTBS) will be investigated over four different sessions (sham tDCS + sham iTBS, anodal tDCS + sham iTBS, anodal tDCS + active iTBS and sham tDCS + active iTBS) in 30 healthy adult volunteers. A 99mTc-ethylene cysteine dimer (99mTC-ECD) will be administered during the NIBS session and neuroimaging will be acquired within one hour. Salivary cortisol will be collected before and after each session and an n-back working memory task will be applied after the end of each NIBS session. The outcomes will be cerebral perfusion alterations (99mTC-ECD SPECT), accuracy and reaction time in the n-back task, and changes in salivary cortisol level.

conclusionThe results from this trial can guide future therapeutic protocols for NIBS treatments stimulating the PFC by demonstrating that the combination of NIBS techniques is feasible, tolerable, and can lead to greater enhancement of PFC activity.

Indexed as

Transcranial Direct Current StimulationAdultCysteineDouble-Blind MethodHumansOrganotechnetium CompoundsPrefrontal CortexRandomized Controlled Trials as TopicTomography, Emission-Computed, Single-PhotonTranscranial Magnetic StimulationCysteineOrganotechnetium Compoundstechnetium Tc 99m bicisatecognitionCombined effectsnon-invasive brain stimulationprefrontal cortexsalivary cortisolspect

Identifiers

PMID34985846
PMCPMC8835391
OpenAlexW3119277807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.