Evidence map›Paper›PMID 34985791›Full record

ArticleAngewandte Chemie (International ed. in English)2022

A Cholesterol Dimer Stabilizes the Inactivated State of an Inward-Rectifier Potassium Channel.

Collin G Borcik, Isaac R Eason, Maryam Yekefallah, Reza Amani, Ruixian Han, Boden H Vanderloop, Benjamin J Wylie

Abstract read
In one paragraph

Article in Angewandte Chemie (International ed. in English), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Molecular mechanisms of Kir channel gating.Biochemical Society transactions · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. bioRxiv : the preprint server for biology · 2026
    Article
  6. Review
  7. Article
  8. A complete 3D-printed tool kit for Solid-State NMR sample and rotor handling.Journal of magnetic resonance (San Diego, Calif. : 1997) · 2024
    Article
  9. Solid-State NMRJournal of magnetic resonance (San Diego, Calif. : 1997) · 2024
    Article
  10. Coordination of bilayer properties by an inward-rectifier KJournal of structural biology: X · 2024
    Article
  11. Cooperative Gating of a KJournal of the American Chemical Society · 2024
    Article
  12. Segmental Dynamics of Membranous Cholesterol are Coupled.Journal of the American Chemical Society · 2023
    Article
  13. Specific Lipid Studies in Complex Membranes by Solid-State NMR Spectroscopy.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article
  14. Article
  15. Spectroscopic signatures of bilayer ordering in native biological membranes.Biochimica et biophysica acta. Biomembranes · 2022
    Article
  16. ACS omega · 2022
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Collin G BorcikDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.
Isaac R EasonDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.
Maryam YekefallahDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.
Reza AmaniDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.
Ruixian HanDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Boden H VanderloopDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.
Benjamin J WylieDepartment of Chemistry and Biochemistry, Texas Tech University, Lubbock, TX 79409, USA.ORCID 0000-0001-8183-2762

Funding

TRD3 NMRbox: Bayesian AnalyticsP41GM111135 · NIGMS · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI HOCH, JEFFREY C · 2015 to 2024
$14.0M
Technologies for Solid-State NMR Data CollectionP41GM136463 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI WESTLER, WILLIAM MILO · 2021 to 2025
$6.4M
The Purchase of a Liquid Chromatography System to facilitate the high-throughput quantification of lipid-protein interactions and membrane ordering using solid-state NMRR35GM124979 · NIGMS · TRUSTEES OF INDIANA UNIVERSITY · PI Benjamin James Wylie · 2017 to 2026
$3.6M
NIGMS NIH HHS P41 GM111135NIGMS NIH HHS P41 GM136463NIGMS NIH HHS R35 GM124979
6 · The paper itself

Abstract

Cholesterol oligomers reside in multiple membrane protein X-ray crystal structures. Yet, there is no direct link between these oligomers and a biological function. Here we present the structural and functional details of a cholesterol dimer that stabilizes the inactivated state of an inward-rectifier potassium channel KirBac1.1. K

Indexed as

Potassium Channels, Inwardly RectifyingCholesterolPotassiumCholesterolPotassiumPotassium Channels, Inwardly RectifyingCholesterolInward-Rectifier K+ ChannelsMembrane ProteinsNMR StructureSolid-State NMR

Identifiers

PMID34985791
PMCPMC8957755

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.