Evidence map›Paper›PMID 34985704›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

Detection of PERK Signaling in the Central Nervous System.

Zhixin Lei, Sarrabeth Stone, Wensheng Lin

Abstract read
PubMed Publisher
In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
1.2field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Zhixin LeiDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Sarrabeth StoneDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA.
Wensheng LinDepartment of Neuroscience, University of Minnesota, Minneapolis, MN, USA. linw@umn.edu.
University of Minnesota · US

Funding

Mechanisms for maintaining ER protein homeostasis in myelinating cellsR01NS105689 · NINDS · UNIVERSITY OF MINNESOTA · PI LIN, WENSHENG · 2018 to 2022
$1.7M
The effects of NF-kB on oligodendrocytes in models of multiple sclerosisR01NS094151 · NINDS · UNIVERSITY OF MINNESOTA · PI LIN, WENSHENG · 2016 to 2020
$1.7M
NINDS NIH HHS R01 NS094151NINDS NIH HHS R01 NS105689
6 · The paper itself

Abstract

In response to endoplasmic reticulum (ER) stress, activation of pancreatic ER kinase (PERK) signaling adapts cells to stressful conditions by phosphorylating eukaryotic translation initiation factor 2α (eIF2α). Phosphorylation of eIF2α inhibits global protein translation but stimulates the expression of numerous stress-responsive genes by inducing the transcription factor ATF4. A large number of studies have shown that activation of PERK signaling has beneficial or detrimental effects in various diseases of the central nervous system (CNS), including neurodegenerative diseases, myelin disorders, CNS injuries, among others. This chapter is devoted to describing the practical methods for the detection of PERK signaling in CNS diseases.

Indexed as

Activating Transcription Factor 4eIF-2 KinaseApoptosisCentral Nervous SystemEndoplasmic Reticulum StressEukaryotic Initiation Factor-2Activating Transcription Factor 4eIF-2 KinaseEukaryotic Initiation Factor-2ATF4CHOPGADD34ImmunofluorescenceNeuronOligodendrocytePERKPhosphorylated eIF2αReal-time PCRWestern blot

Identifiers

PMID34985704
OpenAlexW4205406310

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.