Evidence map›Paper›PMID 34985655›Full record

ArticleMethods in molecular biology (Clifton, N.J.)2022

An In Vitro System to Model the Establishment and Reactivation of HIV-1 Latency in Primary Human CD4+ T Cells.

Rui Li, Fabio Romerio

Abstract read
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In one paragraph

Article in Methods in molecular biology (Clifton, N.J.), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Rui LiDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Fabio RomerioDepartment of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. fromeri2@jhmi.edu.

Funding

Cell Surface Marker Combinations to Identify Latently Infected CD4+ Cells In VivoR21AI106508 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI ROMERIO, FABIO · 2013 to 2014
$653k
A New Insight into HIV-1 Latency Through a Novel in Vitro SystemR21AI084711 · NIAID · UNIVERSITY OF MARYLAND BALTIMORE · PI ROMERIO, FABIO · 2009 to 2010
$421k
NIAID NIH HHS R21 AI084711NIAID NIH HHS R21 AI106508
6 · The paper itself

Abstract

HIV-1 establishes latency primarily by infecting activated CD4+ T cells that later return to quiescence as memory cells. Latency allows HIV-1 to evade immune responses and to persist during antiretroviral therapy, which represents an important problem in clinical practice. Here we describe both the original and a simplified version of HIV-1 latency models that mimics this process using replication competent viruses. Our model allows generation of large numbers of latently infected CD4+ T cell to dissect molecular mechanisms of HIV latency and reactivation.

Indexed as

HIV-1HIV InfectionsCD4-Positive T-LymphocytesCells, CulturedHumansVirus LatencyVirus ReplicationCD4+ T cellsHIV-1LatencyMonocyte-derived dendritic cells

Identifiers

PMID34985655

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.