Evidence map›Paper›PMID 34985618›Full record

ArticleBrain imaging and behavior2021

Distribution and volume analysis of early hemorrhagic contusions by MRI after traumatic brain injury: a preliminary report of the Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx).

Marianna La Rocca, Giuseppe Barisano, Alexis Bennett, Rachael Garner, Jerome Engel, Emily J Gilmore, David L McArthur, Eric Rosenthal, James Stanis, Paul Vespa and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain imaging and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 1 country.

Marianna La RoccaLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA. marianna.larocca@loni.usc.edu.ORCID http://orcid.org/0000-0002-2254-1583
Giuseppe BarisanoLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Alexis BennettLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Rachael GarnerLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Jerome EngelDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Emily J GilmoreComprehensive Epilepsy Center, Department of Neurology, Yale University, New Haven, CT, USA.
David L McArthurDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Eric RosenthalDepartment of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
James StanisLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Paul VespaDavid Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
Frederick WillyerdPhoenix Children's Hospital, Phoenix, AZ, USA.
Lara L ZimmermannUniversity of California Davis Medical Center, Sacramento, CA, USA.
Arthur W TogaLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
Dominique DuncanLaboratory of Neuro Imaging, USC Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, Los Angeles, CA, USA.
EpiBioS4Rx Study Group
University of Southern California · USUniversity of California, Los Angeles · USHarvard University · USPhoenix Children's Hospital · USUniversity of California Davis Medical Center · USYale University · US

Funding

The Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx) Public Engagement CoreU54NS100064 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TOGA, ARTHUR W · 2017 to 2021
$21.7M
SCH: INT: Collaborative Research: Multimodal Signal Analysis and Data Fusion for Post-traumatic EpilepsyR01NS111744 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DUNCAN, DOMINIQUE, ERDOGMUS, DENIZ · 2019 to 2022
$981k
NINDS NIH HHS R01 NS111744NINDS NIH HHS U54 NS100064
6 · The paper itself

Abstract

Traumatic brain injury (TBI) can produce heterogeneous injury patterns including a variety of hemorrhagic and non-hemorrhagic lesions. The impact of lesion size, location, and interaction between total number and location of contusions may influence the occurrence of seizures after TBI. We report our methodologic approach to this question in this preliminary report of the Epilepsy Bioinformatics Study for Antiepileptogenic Therapy (EpiBioS4Rx). We describe lesion identification and segmentation of hemorrhagic contusions by early posttraumatic magnetic resonance imaging (MRI). We describe the preliminary methods of manual lesion segmentation in an initial cohort of 32 TBI patients from the EpiBioS4Rx cohort and the preliminary association of hemorrhagic contusion and edema location and volume to seizure incidence.

Indexed as

Brain Injuries, TraumaticContusionsEpilepsyComputational BiologyHumansMagnetic Resonance ImagingLesion segmentationLesion volume analysisPosttraumatic late seizuresTraumatic brain injury

Identifiers

PMID34985618
PMCPMC9433738
OpenAlexW4205539620

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.