Evidence map›Paper›PMID 34985569›Full record

ReviewApplied microbiology and biotechnology2022

Photosynthetic microorganisms and their bioactive molecules as new product to healing wounds.

Alexsandra Frazão de Andrade, Ana Lúcia Figueiredo Porto, Raquel Pedrosa Bezerra

Abstract readReview
PubMed Publisher
In one paragraph

Review in Applied microbiology and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
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  6. Towards chlorocytes for therapeutic intravascular photosynthesis.Applied microbiology and biotechnology · 2024
    Review
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  11. Emerging Applications ofBioengineering (Basel, Switzerland) · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Alexsandra Frazão de AndradeDepartamento de Morfologia E Fisiologia Animal, Universidade Federal Rural de Pernambuco - UFRPE, Rua Dom Manoel de Medeiros, s/n, Dois Irmãos, Recife, PE, CEP: 52171-900, Brazil.ORCID http://orcid.org/0000-0001-5215-0332
Ana Lúcia Figueiredo PortoDepartamento de Morfologia E Fisiologia Animal, Universidade Federal Rural de Pernambuco - UFRPE, Rua Dom Manoel de Medeiros, s/n, Dois Irmãos, Recife, PE, CEP: 52171-900, Brazil.ORCID http://orcid.org/0000-0001-5561-5158
Raquel Pedrosa BezerraDepartamento de Morfologia E Fisiologia Animal, Universidade Federal Rural de Pernambuco - UFRPE, Rua Dom Manoel de Medeiros, s/n, Dois Irmãos, Recife, PE, CEP: 52171-900, Brazil. raquel.pbezerra@ufrpe.br.ORCID http://orcid.org/0000-0002-1801-2945
Universidade Federal Rural de Pernambuco · BR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 0001
6 · The paper itself

Abstract

Wounds are a public health problem due to long periods required to repair damaged skin, risk of infection, and amputations. Thus, there is a need to obtain new therapeutic agents with less side effects, more effective oxygen delivery, and increased epithelial cell migration. Photosynthetic microorganisms, such as microalgae and cyanobacteria, may be used as a source of biomolecules for the treatment of different injuries. The aim of this review article focuses on healing potential using phytoconstituents from photosynthetic microorganisms. Cyanophyte Spirulina and Chlorophyte Chlorella are more promising due to steroids, triterpenes, carbohydrates, phenols, and proteins such as lectins and phycocyanin. However, there are few reports about identification and specific function of these molecules on the skin. In other microalgae and cyanobacteria genus, high contents of pigments such as β-carotene, chlorophyll a, allophycocyanin, and hydroxypheophytin were detected, but their effects on phases of wound healing is absent yet. The development of new topical drugs from photosynthetic microorganisms could be a potential alternative to maximize healing. KEY POINTS: • Conventional treatment to skin injuries has limitations. • Proteins, terpenes, and phenols increase collagen deposition and re-epithelialization. • Microalgae and cyanobacteria may be used as a source of biomolecules to wound healing.

Indexed as

ChlorellaMicroalgaeChlorophyll ACollagenPhotosynthesisChlorophyll ACollagenBiomoleculesInflammationMicroalgaeNatural products

Identifiers

PMID34985569
OpenAlexW4205881439

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.