Evidence map›Paper›PMID 34985411›Full record

ArticleEmerging microbes & infections2022

Pharmacological suppression of glycogen synthase kinase-3 reactivates HIV-1 from latency via activating Wnt/β-catenin/TCF1 axis in CD4

Jing Wen, Xin Li, Qing-Xia Zhao, Xiao-Fan Yang, Meng-Li Wu, Qihong Yan, Junbiao Chang, Haikun Wang, Xia Jin, Xiao Su and 3 more

Open access · goldAbstract read
In one paragraph

Article in Emerging microbes & infections, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Network Pharmacology-Guided Identification ofInternational journal of molecular sciences · 2026
    Article
  3. Article
  4. A new mRNA antigen vaccine induces potent B and T cell responses andbioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Liver X receptor controls follicular helper T cell differentiation via repression of TCF-1.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 2 countries.

Jing WenInstitut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, People's Republic of China.
Xin LiGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People's Republic of China.
Qing-Xia ZhaoDepartment of Infection, Zhengzhou Sixth People's Hospital, Zhengzhou, People's Republic of China.
Xiao-Fan YangInstitute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China.
Meng-Li WuCollege of Life Science, Henan Normal University, Xinxiang, People's Republic of China.
Qihong YanGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People's Republic of China.
Junbiao ChangCollege of Life Science, Henan Normal University, Xinxiang, People's Republic of China.
Haikun WangInstitut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, People's Republic of China.
Xia JinCollege of Life Science, Henan Normal University, Xinxiang, People's Republic of China.
Xiao SuInstitut Pasteur of Shanghai, Chinese Academy of Sciences, Shanghai, People's Republic of China.
Kai DengInstitute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, People's Republic of China.
Ling ChenGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People's Republic of China.
Jian-Hua WangUniversity of Chinese Academy of Sciences, Beijing, People's Republic of China.
Chinese Academy of Sciences · CNGuangzhou Institutes of Biomedicine and Health · CNHenan Normal University · CNInstitute of Human Virology · NGInstitut Pasteur of Shanghai · CNSun Yat-sen University · CNThe Sixth People's Hospital of Zhengzhou · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Animalsbeta CateninCD4-Positive T-LymphocytesCell Line, TumorGlycogen Synthase Kinase 3HeLa CellsHepatocyte Nuclear Factor 1-alphaHIV-1HumansIndolesMacaca mulattaOximesTranscription, GeneticU937 CellsVirus ActivationVirus Latency6-bromoindirubin-3'-oximebeta CateninCTNNB1 protein, humanGlycogen Synthase Kinase 3Hepatocyte Nuclear Factor 1-alphaHNF1A protein, humanIndolesOximesWnt Proteinsglycogen synthase kinase-3HIV-1TCF1viral latencyβ-catenin

Identifiers

PMID34985411
PMCPMC8812804
OpenAlexW4205916083

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.