Evidence map›Paper›PMID 34985329›Full record

ArticleMicrobiology spectrum2022

Elevated Cerebrospinal Fluid Anti-CD4 Autoantibody Levels in HIV Associate with Neuroinflammation.

Da Cheng, Zhenwu Luo, Xiaoyu Fu, Sophie Stephenson, Clara Di Germanio, Philip J Norris, Dietmar Fuchs, Lishomwa C Ndhlovu, Quan-Zhen Li, Henrik Zetterberg and 4 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.4field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Impact of Anti-CD4 Autoantibodies on Immune Reconstitution in People With Advanced HIV.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2025
    Article
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 5 countries.

Da ChengDepartment of Microbiology and Immunology, Medical University of South Carolinagrid.259828.c, Charleston, South Carolina, USA.
Zhenwu LuoDepartment of Microbiology and Immunology, Medical University of South Carolinagrid.259828.c, Charleston, South Carolina, USA.
Xiaoyu FuDepartment of Microbiology and Immunology, Medical University of South Carolinagrid.259828.c, Charleston, South Carolina, USA.
Sophie StephensonDepartment of Neurology, University of California San Francisco, San Francisco General Hospital, San Francisco, California, USA.
Clara Di GermanioVitalant Research Institute, San Francisco, California, USA.
Philip J NorrisVitalant Research Institute, San Francisco, California, USA.
Dietmar FuchsInstitut für Biologische Chemie, Biozentrum, Medizinische Universität Innsbruck, Innrain, Innsbruck, Austria.
Lishomwa C NdhlovuDepartment of Medicine, Division of Infectious Diseases, Weill Cornell Medicinegrid.471410.7, New York, New York, USA.
Quan-Zhen LiDepartment of Immunology and Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
Henrik ZetterbergDepartment of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Magnus GisslenDepartment of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Richard W PriceDepartment of Neurology, University of California San Francisco, San Francisco General Hospital, San Francisco, California, USA.
Shifang PengDepartment of Infectious Disease, Xiangya Hospital, Central South University, Changsha, China.
Wei JiangDepartment of Microbiology and Immunology, Medical University of South Carolinagrid.259828.c, Charleston, South Carolina, USA.ORCID 0000-0003-2769-2812
Central South University · CNMedical University of South Carolina · USSahlgrenska University Hospital · SESan Francisco General Hospital · USUniversity of California, San Francisco · USCornell University · USInnsbruck Medical University · ATThe University of Texas Southwestern Medical Center · US

Funding

Compartmentalized CSF viral escape and the CNS HIV reservoirR01NS094067 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRICE, RICHARD W. · 2015 to 2020
$3.9M
On the pathogenic role of anti-CD4 antibody in poor CD4+ T cell recovery after antiretroviral therapy in HIV diseaseR01AI128864 · NIAID · MEDICAL UNIVERSITY OF SOUTH CAROLINA · PI JIANG, WEI · 2017 to 2021
$1.1M
CSRD VA I01 CX002422NIAID NIH HHS R01 AI128864NINDS NIH HHS R01 NS094067
6 · The paper itself

Abstract

The mechanisms of persistent central nervous system (CNS) inflammation in people with HIV (PWH) despite effective antiretroviral therapy (ART) are not fully understood. We have recently shown that plasma anti-CD4 IgGs contribute to poor CD4

Indexed as

AdultAutoantigensBiomarkersCD4 AntigensCentral Nervous SystemCytokinesFemaleHIV InfectionsHumansImmunoglobulin GMaleMiddle AgedNeurofilament ProteinsNeuroinflammatory DiseasesAutoantigensBiomarkersCD4 AntigensCytokinesImmunoglobulin Gneurofilament protein LNeurofilament Proteinsanti-CD4 autoantibodyanti-CD4 IgGcerebrospinal fluidHIVHIV-1 infectionneuroinflammation

Identifiers

PMID34985329
PMCPMC8729763
OpenAlexW4205282985

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.