Evidence map›Paper›PMID 34985305›Full record

Observational studyEnvironmental health perspectives2022

Biodigester Cookstove Interventions and Child Diarrhea in Semirural Nepal: A Causal Analysis of Daily Observations.

Heather K Amato, Caitlin Hemlock, Kristin L Andrejko, Anna R Smith, Nima S Hejazi, Alan E Hubbard, Sharat C Verma, Ramesh K Adhikari, Dhiraj Pokhrel, Kirk Smith and 2 more

Abstract readObservational Study
In one paragraph

Observational study in Environmental health perspectives, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors.

Heather K AmatoDivision of Environmental Health Sciences, University of California, Berkeley School of Public Health, Berkeley, California, USA.ORCID 0000-0002-0501-0756
Caitlin HemlockDivision of Epidemiology, University of California, Berkeley School of Public Health, Berkeley, California, USA.ORCID 0000-0002-1714-1016
Kristin L AndrejkoDivision of Epidemiology, University of California, Berkeley School of Public Health, Berkeley, California, USA.ORCID 0000-0002-0808-0231
Anna R SmithDivision of Environmental Health Sciences, University of California, Berkeley School of Public Health, Berkeley, California, USA.ORCID 0000-0003-1047-3859
Nima S HejaziDivision of Biostatistics, University of California, Berkeley School of Public Health, Berkeley, California, USA.ORCID 0000-0002-7127-2789
Alan E HubbardDivision of Biostatistics, University of California, Berkeley School of Public Health, Berkeley, California, USA.ORCID 0000-0002-3769-0127
Sharat C VermaNational Tuberculosis Center, Kathmandu, Nepal.
Ramesh K AdhikariTribhuvan University, Institute of Medicine, Maharajgunj Medical Campus, Kathmandu, Nepal.
Dhiraj PokhrelSociety for Legal and Environmental Analysis and Development Research (LEADERS), Nepal.
Kirk SmithDivision of Environmental Health Sciences, University of California, Berkeley School of Public Health, Berkeley, California, USA.
Jay P GrahamDivision of Environmental Health Sciences, University of California, Berkeley School of Public Health, Berkeley, California, USA.ORCID 0000-0001-7062-6293
Amod PokhrelDivision of Environmental Health Sciences, University of California, Berkeley School of Public Health, Berkeley, California, USA.ORCID 0000-0002-6478-7442

Funding

Effects of geospatial factors and health worker characteristics on child health: implications for interventions in low-resource settingsF31HD105418 · NICHD · UNIVERSITY OF CALIFORNIA BERKELEY · PI HEMLOCK, CAITLIN · 2021 to 2023
$83k
NICHD NIH HHS F31 HD105418
6 · The paper itself

Abstract

backgroundHundreds of thousands of biodigesters have been constructed in Nepal. These household-level systems use human and animal waste to produce clean-burning biogas used for cooking, which can reduce household air pollution from woodburning cookstoves and prevent respiratory illnesses. The biodigesters, typically operated by female caregivers, require the handling of animal waste, which may increase domestic fecal contamination, exposure to diarrheal pathogens, and the risk of enteric infections, especially among young children.

objectiveWe estimated the effect of daily reported biogas cookstove use on incident diarrhea among children

methodsWe analyzed 300,133 person-days for 539 children in an observational prospective cohort study to estimate the average effect of biogas stove use on incident diarrhea using cross-validated targeted maximum likelihood estimation (CV-TMLE).

resultsHouseholds reported using biogas cookstoves in the past 3 d for 23% of observed person-days. The adjusted relative risk of diarrhea for children exposed to biogas cookstove use was 1.31 (95% confidence interval (CI): 1.00, 1.71) compared to unexposed children. The estimated effect of biogas stove use on diarrhea was stronger among breastfed children (2.09; 95% CI: 1.35, 3.25) than for nonbreastfed children and stronger during the dry season (2.03; 95% CI: 1.17, 3.53) than in the wet season. Among children exposed to biogas cookstove use, those with a recent ALRI had the highest mean risk of diarrhea, estimated at 4.53 events (95% CI: 1.03, 8.04) per 1,000 person-days. DISCUSSION: This analysis provides new evidence that child diarrhea may be an unintended health risk of biogas cookstove use. Additional studies are needed to identify exposure pathways of fecal pathogen contamination associated with biodigesters to improve the safety of these widely distributed public health interventions. https://doi.org/10.1289/EHP9468.

Indexed as

Air Pollution, IndoorCookingDiarrheaFemaleHumansNepalProspective Studies

Identifiers

PMID34985305
PMCPMC8729225

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.