Evidence map›Paper›PMID 34985282›Full record

ArticleBioconjugate chemistry2022

Assembly of Bleomycin Saccharide-Decorated Spherical Nucleic Acids.

Ville Tähtinen, Vijay Gulumkar, Sajal K Maity, Ann-Mari Yliperttula, Saara Siekkinen, Toni Laine, Ekaterina Lisitsyna, Iida Haapalehto, Tapani Viitala, Elina Vuorimaa-Laukkanen and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Bioconjugate chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.9field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Formation and cellular uptake of Bleomycin saccharide decorated molecular spherical nucleic acids evaluated by time-resolved fluorescence spectroscopy.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2026
    Article
  3. Review
  4. Chondroitin Sulfate-Coated Heteroduplex-Molecular Spherical Nucleic Acids.Chembiochem : a European journal of chemical biology · 2025
    Article
  5. Article
  6. Article
  7. Molecular pharmaceutics · 2023
    Article
  8. Review
  9. Article
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Ville TähtinenDepartment of Chemistry, University of Turku, FI-20500 Turku, Finland.
Vijay GulumkarDepartment of Chemistry, University of Turku, FI-20500 Turku, Finland.
Sajal K MaityDepartment of Chemistry, University of Turku, FI-20500 Turku, Finland.
Ann-Mari YliperttulaDepartment of Chemistry, University of Turku, FI-20500 Turku, Finland.
Saara SiekkinenDepartment of Chemistry, University of Turku, FI-20500 Turku, Finland.
Toni LaineDepartment of Chemistry, University of Turku, FI-20500 Turku, Finland.
Ekaterina LisitsynaFaculty of Engineering and Natural Sciences, Tampere University, FI-33014 Tampere, Finland.
Iida HaapalehtoFaculty of Engineering and Natural Sciences, Tampere University, FI-33014 Tampere, Finland.
Tapani ViitalaDivision of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland.ORCID 0000-0001-9074-9450
Elina Vuorimaa-LaukkanenFaculty of Engineering and Natural Sciences, Tampere University, FI-33014 Tampere, Finland.
Marjo YliperttulaDivision of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, FI-00014 Helsinki, Finland.ORCID 0000-0003-0726-5733
Pasi VirtaDepartment of Chemistry, University of Turku, FI-20500 Turku, Finland.ORCID 0000-0002-6218-2212
University of Turku · FITampere University · FIUniversity of Helsinki · FIÅbo Akademi University · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Glyco-decorated spherical nucleic acids (SNAs) may be attractive delivery vehicles, emphasizing the sugar-specific effect on the outer sphere of the construct and at the same time hiding unfavorable distribution properties of the loaded oligonucleotides. As examples of such nanoparticles, tripodal sugar constituents of bleomycin were synthesized and conjugated with a fluorescence-labeled antisense oligonucleotide (AON

Indexed as

BleomycinNucleic AcidsCycloaddition ReactionHumansOligonucleotides, AntisensePC-3 CellsBleomycinNucleic AcidsOligonucleotides, Antisense

Identifiers

PMID34985282
PMCPMC8778632
OpenAlexW4205794227

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.