Evidence map›Paper›PMID 34985237›Full record

Trial reportEuropean journal of physical and rehabilitation medicine2022

Comparing hip and knee focused exercises versus hip and knee focused exercises with the use of blood flow restriction training in adults with patellofemoral pain.

Antonis Constantinou, Ioannis Mamais, Giorgos Papathanasiou, Demetris Lamnisos, Dimitrios Stasinopoulos

2 registry-linked trialsOpen access · diamondAbstract readRandomized Controlled Trial
In one paragraph

Trial report in European journal of physical and rehabilitation medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 6 pooled it
8.6field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05617911 naterminatednot on this map

Clinical Comparison of Patellofemoral Pain Syndrome Outcomes After Blood Flow Restriction Therapy

TypeinterventionalSponsorGaylord Hospital, IncRan2022 to 2023Enrolled1ConditionsPatellofemoral Pain Syndrome, Anterior Knee Pain SyndromeArmsBlood Flow Restriction Cuff, Sham and standard of Care Therapy
NCT07013617 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effect Of Hamstring Stretch On Clinical Outcomes In Patellofemoral Pain Syndrome

TypeinterventionalSponsorCairo UniversityRan2025 to 2025Enrolled60ConditionsHamstring Shortness, Patellofemoral Pain Syndrome, Hamstring Flexibility, Patellofemoral Pain (PFPS)ArmsTranscutaneous Electrical Nerve Stimulation Device, Strength exercises for lower limb, Hamstring Stretch Muscle Energy Technique(MET) (General ), Medial Hamstring Muscle energy technique(MET) stretch, Lateral hamstring Muscle Energy Technique(MET)Stretch
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 6 syntheses or guidelines pooled it, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Antonis ConstantinouDepartment of Health Sciences, European University Cyprus, Nicosia, Cyprus - an.constantinou@euc.ac.cy.
Ioannis MamaisDepartment of Health Sciences, School of Sciences, European University Cyprus, Nicosia Cyprus.
Giorgos PapathanasiouDepartment of Physiotherapy, Director of Laboratory of Neuromuscular and Cardiovascular Study of Motion (LANECASM), Faculty of Health and Caring Sciences, University of West Attica, Athens, Greece.
Demetris LamnisosDepartment of Health Sciences, Cyprus Musculoskeletal and Sports Trauma Research Centre (CYMUSTREC) Physiotherapy Program, School of Sciences, European University Cyprus, Nicosia, Cyprus.
Dimitrios StasinopoulosDepartment of Physiotherapy, Faculty of Health and Caring Sciences, University of West Attica, Athens, Greece.
European University Cyprus · CYUniversity of West Attica · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHip and knee strengthening exercises are implemented in rehabilitation of patellofemoral pain patients, but typically use high loads (70% of 1 repetition maximum). This may lead to increased patellofemoral joint stress. Low load training (20-30% of 1 repetition maximum) with blood flow restriction could allow for exercise strength benefits to proximal and distal muscles with reduced joint stress and by promoting hypoalgesia.

aimThe aim of this study was to compare hip and knee focused exercises with and without blood flow restriction in adults with patellofemoral pain for short term effectiveness.

designA randomized observed-blind controlled trial.

settingMusculoskeletal laboratories of the European University Cyprus, Nicosia, Cyprus. POPULATION: 60 volunteer patients, 18-40 years of age with patellofemoral pain.

methodsParticipants were randomly assigned to (1 reference group) hip and knee strengthening at (70% of 1 repetition maximum) or (2 experimental group) Strengthening with blood flow restriction at (30% of 1 repetition maximum at 70% of limb occlution pressure). Treatments took place 3 times per week for 4weeks and outcomes were assessed at baseline, end of treatment and at 2-month follow-up. The primary outcome was the Kujala Anterior Knee Pain Scale and secondary outcomes were worst and usual pain, pain with Single leg Squats, the maximum pain free flexion angle, the Tampa Scale of kinesiophobia, the Pain Catastrophizing Scale and isometric strength of knee extensors, hip extensors and hip abductors.

resultsNo difference were found for the main outcome of this study between groups. There was a significant effect of time for all outcome measures in both groups. Between group differences showed a significant difference for isometric strength of Knee extensor values at 2 month follow-up F(1,58)=5.56, P=0.02, partial η2=0.09, 459.4 (412.13, 506.64) vs. 380.68 (333.42, 427.93) and in worst pain post-treatment F(1,58)=5.27, P=0.02, partial η

conclusionsBlood flow restriction exercises of the hip and knee musculature used in this study were as effective as usual exercises of Hip and knee musculature in reducing symptoms in the short term. They also indicated greater increases in strength and reduction of worst pain post-treatment. CLINICAL REHABILITATION IMPACT: Further research is needed to investigate the dose response relationship with longer follow-ups.

Indexed as

Patellofemoral Pain SyndromeResistance TrainingAdultBlood Flow Restriction TherapyExercise TherapyHumansMuscle StrengthPain

Identifiers

PMID34985237
PMCPMC9980495
OpenAlexW4205569816

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.