Trial reportEuropean journal of physical and rehabilitation medicine2022
Comparing hip and knee focused exercises versus hip and knee focused exercises with the use of blood flow restriction training in adults with patellofemoral pain.
Trial report in European journal of physical and rehabilitation medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 22 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Clinical Comparison of Patellofemoral Pain Syndrome Outcomes After Blood Flow Restriction Therapy
Effect Of Hamstring Stretch On Clinical Outcomes In Patellofemoral Pain Syndrome
Who cites it
22 citing papers in PubMed, 6 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Blood flow restriction training for lower limb injury prevention and rehabilitation in dancers: a scoping review of current evidence and future directions.BMC sports science, medicine & rehabilitation · 2026Pooled it
- Effects of blood flow restriction exercise interventions on patellofemoral pain syndrome: a systematic review and meta-analysis.Frontiers in physiology · 2026Pooled it
- Knee extensor training in patients with patellofemoral pain: a systematic review and synthesis.Frontiers in rehabilitation sciences · 2025Pooled it
- Effects of blood flow restrictiontraining on muscle function and balance in chronic ankle instability: a systematic review.Frontiers in physiology · 2025Pooled it
- Kinesiophobia Is Associated With Poor Function and Modifiable Through Interventions in People With Patellofemoral Pain: A Systematic Review With Individual Participant Data Correlation Meta-Analysis.Physical therapy · 2023Pooled it
- Effectiveness of Blood Flow Restriction on Functionality, Quality of Life and Pain in Patients with Neuromusculoskeletal Pathologies: A Systematic Review.International journal of environmental research and public health · 2023Pooled it
- Patient characteristics modify the effects of education plus exercise on patellofemoral joint loading: a secondary effect-modifier analysis of a randomized controlled trial.Scientific reports · 2026Trial
- Exercise-Induced Hypoalgesia Following Blood Flow Restriction in Rotator Cuff Repair Rehabilitation: A Randomized Crossover Clinical Trial.Translational sports medicine · 2026Article
- Cardiovascular responses during blood flow-restricted resistance exercise: a systematic review with meta-analysis.BMJ open sport & exercise medicine · 2026Article
- Comparative Analysis of Mechanical Variables in Different Exercises Performed with a Rotational Inertial Device in Professional Soccer Players: A Pilot Study.Journal of functional morphology and kinesiology · 2025Article
- MRI analysis of the physiological patellofemoral joint morphology of adult knees.Skeletal radiology · 2025Article
- Effect of heel height on patellofemoral joint stress during stair descent.Scientific reports · 2025Article
- [Dynamic and Static Complementary Balance Theory-Based Functional Exercise Combined With Stepwise Rehabilitation Training Improves Postoperative Hip Function Recovery in Patients Undergoing Total Hip Replacement].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024Article
- Study on the effect of blood flow restriction training combined with IASTAM on ankle strength and function intervention in athletes with chronic ankle instability in sport dance events.BMC sports science, medicine & rehabilitation · 2024Article
- Effect of 6-week BFRT combined with IASTAM therapy on international standard dancers with chronic ankle instability.Frontiers in physiology · 2024Article
- Impact of telehealth-based therapeutic exercise on pain, functional performance and dynamic knee valgus in young adult females with patellofemoral pain: a randomised controlled trial.BMJ open sport & exercise medicine · 2024Article
- Global research trends and hotspots in patellofemoral pain syndrome from 2000 to 2023: a bibliometric and visualization study.Frontiers in medicine · 2024Article
- Effects of blood-flow restricted exercise versus conventional resistance training in musculoskeletal disorders-a systematic review and meta-analysis.BMC sports science, medicine & rehabilitation · 2023Article
- Article
- Blood Flow Restriction Training in Nonspecific Shoulder Pain: Study Protocol of a Crossover Randomised Controlled Trial.Sports (Basel, Switzerland) · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHip and knee strengthening exercises are implemented in rehabilitation of patellofemoral pain patients, but typically use high loads (70% of 1 repetition maximum). This may lead to increased patellofemoral joint stress. Low load training (20-30% of 1 repetition maximum) with blood flow restriction could allow for exercise strength benefits to proximal and distal muscles with reduced joint stress and by promoting hypoalgesia.
aimThe aim of this study was to compare hip and knee focused exercises with and without blood flow restriction in adults with patellofemoral pain for short term effectiveness.
designA randomized observed-blind controlled trial.
settingMusculoskeletal laboratories of the European University Cyprus, Nicosia, Cyprus. POPULATION: 60 volunteer patients, 18-40 years of age with patellofemoral pain.
methodsParticipants were randomly assigned to (1 reference group) hip and knee strengthening at (70% of 1 repetition maximum) or (2 experimental group) Strengthening with blood flow restriction at (30% of 1 repetition maximum at 70% of limb occlution pressure). Treatments took place 3 times per week for 4weeks and outcomes were assessed at baseline, end of treatment and at 2-month follow-up. The primary outcome was the Kujala Anterior Knee Pain Scale and secondary outcomes were worst and usual pain, pain with Single leg Squats, the maximum pain free flexion angle, the Tampa Scale of kinesiophobia, the Pain Catastrophizing Scale and isometric strength of knee extensors, hip extensors and hip abductors.
resultsNo difference were found for the main outcome of this study between groups. There was a significant effect of time for all outcome measures in both groups. Between group differences showed a significant difference for isometric strength of Knee extensor values at 2 month follow-up F(1,58)=5.56, P=0.02, partial η2=0.09, 459.4 (412.13, 506.64) vs. 380.68 (333.42, 427.93) and in worst pain post-treatment F(1,58)=5.27, P=0.02, partial η
conclusionsBlood flow restriction exercises of the hip and knee musculature used in this study were as effective as usual exercises of Hip and knee musculature in reducing symptoms in the short term. They also indicated greater increases in strength and reduction of worst pain post-treatment. CLINICAL REHABILITATION IMPACT: Further research is needed to investigate the dose response relationship with longer follow-ups.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.