Evidence map›Paper›PMID 34984951›Full record

ArticleIntegrative cancer therapies

A Case Study Using Papaya Leaf Extract to Reverse Chemotherapy-Induced Thrombocytopenia in a GBM Patient.

Abigail Koehler, Rohan Rao, Yehudit Rothman, Yair M Gozal, Timothy Struve, Lise Alschuler, Soma Sengupta

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Integrative cancer therapies. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
3.1field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Abigail KoehlerUniversity of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID 0000-0002-2961-0836
Rohan RaoUniversity of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID 0000-0002-7166-1899
Yehudit RothmanUniversity of Cincinnati College of Medicine, Cincinnati, OH, USA.
Yair M GozalMayfield Clinic, Cincinnati, OH, USA.
Timothy StruveUniversity of Cincinnati College of Medicine, Cincinnati, OH, USA.
Lise AlschulerThe University of Arizona College of Medicine, Tucson, AZ, USA.
Soma SenguptaUniversity of Cincinnati College of Medicine, Cincinnati, OH, USA.ORCID 0000-0003-4577-1397
University of Cincinnati Medical Center · USMayfield Brain & Spine · USUniversity of Arizona · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chemotherapy-induced thrombocytopenia (CIT) is a critical condition in which platelet counts are abnormally reduced following the administration of chemotherapeutic compounds. CIT poses a treatment conundrum to clinicians given the increased risk of spontaneous bleeding, obstacles to surgical management of tumors, and exclusion from clinical trials. Treatment of CIT involves the removal of the offending agent combined with platelet infusion or thrombopoietin agonist treatment. However, due to the autoimmune and infection risks associated with infusions, this treatment is only reserved for patients with critically low platelet counts. One potential solution for patients in the mid to low platelet count range is

Indexed as

Antineoplastic AgentsCaricaThrombocytopeniaHumansPlant ExtractsThrombopoietinVegetablesAntineoplastic AgentsPlant ExtractsThrombopoietinCarica papayachemotherapy-induced thrombocytopeniaGlioblastoma multiformepapaya leaf extractplateletstemozolomide

Identifiers

PMID34984951
PMCPMC8753228
OpenAlexW4205096477

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.