Evidence map›Paper›PMID 34984926›Full record

ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2022

Cyclooxygenase-2 deficiency attenuates lipopolysaccharide-induced inflammation, apoptosis, and acute lung injury in adult mice.

Leif D Nelin, Yi Jin, Bernadette Chen, Yusen Liu, Lynette K Rogers, Jeff Reese

Open access · greenAbstract read
In one paragraph

Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. The inhibitory effects ofFood science and biotechnology · 2026
    Article
  3. Article
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  5. Article
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  10. International journal of molecular sciences · 2022
    Article
  11. Article
  12. Yangyinqingfei decoction attenuates PMFrontiers in pharmacology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Leif D NelinPulmonary Hypertension Group, Center for Perinatal Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio.ORCID 0000-0002-3722-3035
Yi JinPulmonary Hypertension Group, Center for Perinatal Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio.
Bernadette ChenPulmonary Hypertension Group, Center for Perinatal Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio.
Yusen LiuPulmonary Hypertension Group, Center for Perinatal Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio.
Lynette K RogersPulmonary Hypertension Group, Center for Perinatal Research, Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, Ohio.ORCID 0000-0003-3413-5379
Jeff ReeseDepartment of Pediatrics, Vanderbilt University, Nashville, Tennessee.
Nationwide Children's Hospital · USVanderbilt University · US

Funding

Regulation of PDE3 in the Pathobiology of Pulmonary HypertensionR01HL136963 · NHLBI · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI CHEN, BERNADETTE · 2018 to 2022
$2.4M
NHLBI NIH HHS R01 HL136963
6 · The paper itself

Abstract

Many lung diseases are caused by an excessive inflammatory response, and inflammatory lung diseases are often modeled using lipopolysaccharide (LPS) in mice. Cyclooxygenase-2 (COX-2) encoded by the

Indexed as

ApoptosisAcute Lung InjuryAnimalsCaspase 3Caspase 9Chemokine CCL2Cyclooxygenase 2Disease Models, AnimalFemaleInterleukin-10LipopolysaccharidesLungMaleMiceMice, KnockoutPneumoniaCasp3 protein, mouseCasp9 protein, mouseCaspase 3Caspase 9Ccl2 protein, mouseChemokine CCL2Cyclooxygenase 2IL10 protein, mouseInterleukin-10LipopolysaccharidesPtgs2 protein, mouseTnf protein, mouseTumor Necrosis Factor-alphacytokinesinflammationprostaglandinspulmonary edemapulmonary function

Identifiers

PMID34984926
PMCPMC9829472
OpenAlexW4205656747

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.