Evidence map›Paper›PMID 34984761›Full record

ArticleJournal of peptide science : an official publication of the European Peptide Society2022

Backbone distortions in lactam-bridged helical peptides.

Ali Moazzam, Vesna Stanojlovic, Arthur Hinterholzer, Christoph Holzner, Cornelia Roschger, Andreas Zierer, Markus Wiederstein, Mario Schubert, Chiara Cabrele

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of peptide science : an official publication of the European Peptide Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Backbone distortions in lactam-bridged helical peptides.Journal of peptide science : an official publication of the European Peptide Society · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Ali MoazzamDepartment of Biosciences, Paris Lodron University of Salzburg, Salzburg, Austria.
Vesna StanojlovicDepartment of Biosciences, Paris Lodron University of Salzburg, Salzburg, Austria.
Arthur HinterholzerDepartment of Biosciences, Paris Lodron University of Salzburg, Salzburg, Austria.
Christoph HolznerDepartment of Biosciences, Paris Lodron University of Salzburg, Salzburg, Austria.
Cornelia RoschgerDepartment for Cardiac-, Vascular- and Thoracic Surgery, Johannes Kepler University Linz and Kepler University Hospital GmbH, Linz, Austria.
Andreas ZiererDepartment for Cardiac-, Vascular- and Thoracic Surgery, Johannes Kepler University Linz and Kepler University Hospital GmbH, Linz, Austria.
Markus WiedersteinDepartment of Biosciences, Paris Lodron University of Salzburg, Salzburg, Austria.
Mario SchubertDepartment of Biosciences, Paris Lodron University of Salzburg, Salzburg, Austria.ORCID https://orcid.org/0000-0003-0278-4091
Chiara CabreleDepartment of Biosciences, Paris Lodron University of Salzburg, Salzburg, Austria.ORCID https://orcid.org/0000-0002-7550-6896
University of Salzburg · ATJohannes Kepler University of Linz · AT

Funding

Land SalzburgMinistry of Science and Technology of Iran and University of TehranUniversity of Salzburg
6 · The paper itself

Abstract

Side-chain-to-side-chain cyclization is frequently used to stabilize the α-helical conformation of short peptides. In a previous study, we incorporated a lactam bridge between the side chains of Lys-i and Asp-i+4 in the nonapeptide 1Y, cyclo-(2,6)-(Ac-VKRLQDLQY-NH

Indexed as

IsoleucineLactamsCircular DichroismPeptidesPeptides, CyclicProtein ConformationProtein Structure, SecondaryTyrosineValineIsoleucineLactamsPeptidesPeptides, CyclicTyrosineValinecarbonyl tiltingcircular dichroismlactam bridgeNMR spectroscopyα-helix

Identifiers

PMID34984761
PMCPMC9285742
OpenAlexW4205324908

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.