Evidence map›Paper›PMID 34984723›Full record

ArticleJournal of clinical laboratory analysis2022

Bone mineral density, bone metabolism-related factors, and microRNA-218 are correlated with disease activities in Chinese ankylosing spondylitis patients.

Jiayan Liu, Li Zhao, Xue Yang, Congjin Liu, Ning Kong, Yiyun Yu, Dandan Xuan, Weiguo Wan, Yu Xue

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In one paragraph

Article in Journal of clinical laboratory analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Jiayan LiuDepartment of Rheumatology, Jiading District Central Hospital Affiliated Shanghai University of Medicine & Health Sciences, Shanghai, China.
Li ZhaoInstitute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China.
Xue YangInstitute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China.
Congjin LiuInstitute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China.
Ning KongInstitute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China.
Yiyun YuInstitute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China.
Dandan XuanInstitute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China.
Weiguo WanInstitute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0003-1095-8354
Yu XueInstitute of Rheumatology, Immunology and Allergy, Fudan University, Shanghai, China.

Funding

Pujiang Rheumatism Youth Cultivation Program SPROG1808
6 · The paper itself

Abstract

objectiveTo investigate bone mineral density (BMD), bone metabolism-related factors, and microRNA-218 in Chinese ankylosing spondylitis (AS) patients and to identify their correlation with disease activities and the treatment with TNF-α inhibitors.

methodsA total of 89 AS patients were enrolled in the study. Patients' information and laboratory examination results were collected. BMD of the anteroposterior lumbar spine (L2-L4), left femoral neck, and whole body were measured and T-scores were calculated. MicroRNA-218 was extracted from PBMCs of AS patients and detected by RT-PCR. Bone metabolism-related factors were detected using protein chips and flow cytometer.

resultsOut of 86 patients undergoing whole-body BMD measurement, 14 had osteopenia and 72 had normal BMD without osteoporosis or high BMD. Compared with short- (disease duration ≤3 years) and long-term groups (disease duration ≥10 years), medium-term group (disease duration ranges from 3 to 10 years) showed lowest BMD. Patients with onset age ≤20 years old had significantly lower BMD than the other groups (p < 0.05). The BMD of femoral neck had negative correlation with CRP (p < 0.05) and no correlation with BASDAI or ESR. Both whole-body BMD and femoral neck BMD were negatively correlated with BASMI (p < 0.05). Dickkopf-1 (DKK-1), platelet-derived growth factor-BB (PDGF-BB), and receptor activator of NF-κB ligand (RANKL)/osteoprotegerin (OPG) were significantly increased, while Osteopontin (OPN) was significantly decreased in AS patients. Expression of microRNA-218 in PBMC of AS patients was low and was positively correlated with BASMI (p < 0.05), but it was not correlated with the duration of disease, age of onset, BASDAI, ESR, or BMD.

conclusionLoss of bone mass mainly occurred at the inflammatory sites in AS patients, depending on the severity of inflammation. The alleviation of inflammation can improve loss of bone mass and bone metabolism disorders. Anti-inflammatory treatment is critical for the treatment of secondary osteoporosis caused by AS.

Indexed as

Bone DensityAbsorptiometry, PhotonAdultBone and BonesBone Diseases, MetabolicChinaFemaleFemur NeckFlow CytometryHumansLumbar VertebraeMaleMicroRNAsOsteoporosisRange of Motion, ArticularReverse Transcriptase Polymerase Chain ReactionMicroRNAsMIRN218 microRNA, humanTumor Necrosis Factor Inhibitorsankylosing spondylitisbone metabolismbone mineral densitymicroRNA-218

Identifiers

PMID34984723
PMCPMC8842167

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.