Evidence map›Paper›PMID 34984591›Full record

ArticleTransgenic research2022

Skeletal muscle phenotyping of Hippo gene-mutated mice reveals that Lats1 deletion increases the percentage of type I muscle fibers.

Fakhreddin Yaghoob Nezhad, Annett Riermeier, Martin Schönfelder, Lore Becker, Martin Hrabĕ de Angelis, Henning Wackerhage

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Transgenic research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Fakhreddin Yaghoob NezhadExercise Biology Group, Faculty of Sport and Health Sciences, Technical University of Munich, Munich, Germany.ORCID 0000-0001-8518-8409
Annett RiermeierExercise Biology Group, Faculty of Sport and Health Sciences, Technical University of Munich, Munich, Germany.
Martin SchönfelderExercise Biology Group, Faculty of Sport and Health Sciences, Technical University of Munich, Munich, Germany.
Lore BeckerGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0002-6890-4984
Martin Hrabĕ de AngelisGerman Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg, Germany.ORCID 0000-0002-7898-2353
Henning WackerhageExercise Biology Group, Faculty of Sport and Health Sciences, Technical University of Munich, Munich, Germany. henning.wackerhage@tum.de.ORCID 0000-0001-5920-5842
Technical University of Munich · DEHelmholtz Zentrum München · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Hippo signal transduction network regulates transcription through Yap/Taz-Tead1-4 in many tissues including skeletal muscle. Whilst transgenic mice have been generated for many Hippo genes, the resultant skeletal muscle phenotypes were not always characterized. Here, we aimed to phenotype the hindlimb muscles of Hippo gene-mutated Lats1

Indexed as

Muscle, SkeletalSignal TransductionAnimalsHypertrophyMiceMuscle Fibers, SkeletalProtein Serine-Threonine KinasesRNA, MessengerLats1 protein, mouseProtein Serine-Threonine KinasesRNA, MessengerFiber typeHippo pathwayLats1Skeletal muscleTransgenic mice

Identifiers

PMID34984591
PMCPMC8993742
OpenAlexW4205626876

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.