ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2022
Family ties: the impact of celiac disease on children and caregivers.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Trial
- The Multidimensional Impact of Gluten-Free Diet Adherence on Quality of Life in Pediatric and Adolescent Celiac Disease: A Systematic Review.Children (Basel, Switzerland) · 2026Review
- Psychosocial Impact of Celiac Disease on Primary Caregivers of Children in Jordan: A Cross-Sectional Study.Children (Basel, Switzerland) · 2026Article
- Celiac disease in children with focus on symptoms and quality of life.Scientific reports · 2025Article
- Development and Validation of a Pediatric Celiac Disease-Specific Quality of Life Measure.The American journal of gastroenterology · 2025Article
- Observational
- Empiric elimination diets for eosinophilic esophagitis: Barriers, facilitators, and impact on quality of life.The journal of allergy and clinical immunology. In practice · 2025Article
- Living with Pediatric Coeliac Disease: Lessons for Health Service Delivery.Digestive diseases and sciences · 2025Article
- Celiac Disease, Gluten-Free Diet, and Eating Disorders: From Bench to Bedside.Foods (Basel, Switzerland) · 2024Article
- Psychiatric Difficulties in Children with Celiac Disease and the Relationship between Adherence to Treatment and Parental Attitudes.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2024Article
- Vulnerability in Children with Celiac Disease: Findings from a Scoping Review.Children (Basel, Switzerland) · 2024Article
- Study Protocol for a Controlled Trial of Nutrition Education Intervention about Celiac Disease in Primary School: ZELIAKIDE Project.Nutrients · 2024Article
- Elimination Diet or Swallowed Topical Steroid Treatment of Pediatric Eosinophilic Esophagitis: Five-Year Outcomes.The journal of allergy and clinical immunology. In practice · 2023Article
- The Association between ADHD and Celiac Disease in Children.Children (Basel, Switzerland) · 2022Review
- The Relations Among GI Symptoms, Mental Health, and Online Schooling for Youth With GI Conditions During the COVID-19 Pandemic.Journal of developmental and behavioral pediatrics : JDBPArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the impact of celiac disease (CD) and the gluten-free diet (GFD) on the health-related quality of life (HRQoL) in children with CD in the United States using validated measures. We hypothesize that CD negatively impacts the child and caregivers' HRQoL.
methodsParticipants included children with a confirmed diagnosis of CD and their caregivers (n = 246) seen in a CD multidisciplinary clinic. Caregivers completed the Pediatric Quality of Life (PedsQL) parent-proxy scale to report on their child's HRQoL and the Family Impact Module (FIM), which assesses the impact of caring for a child with a chronic illness. Their children completed the age-appropriate PedsQL. PedsQL and FIM results were compared to published data for children with gastroenterological conditions and a healthy cohort using non-parametric tests.
resultsChildren with CD reported significantly lower HRQoL than reports from healthy controls across all PedsQL domains (P < 0.001, Cohen d = 0.8), and lower compared to children with other organic gastrointestinal conditions in Social Functioning (P < 0.001, Cohen d = 0.5) and overall Psychosocial Functioning (P < 0.001, Cohen d = 0.3) domains. Results from the caregiver's report on their own HRQoL were significantly worse than that reported by historical controls in the domains of Communication (P < 0.001, Cohen d = 0.3) and Worry (P < 0.001, Cohen d = 0.8), yet similar on all other domains.
conclusionsIn our population, CD is associated with low HRQoL scores for both children and their caregivers. Screening children and families for HRQoL can identify patients and families in need of additional support in this higher-risk population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.