ArticlePlant cell reports2022
Characterization of lipid droplets from a Taxus media cell suspension and their potential involvement in trafficking and secretion of paclitaxel.
Article in Plant cell reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 15 citations in OpenAlex.
- Plant Lipid Droplets and Derived Lipidic Nano-Assemblies: Structure, Biogenesis and Pharmaceutical Applications.Plant biotechnology journal · 2026Review
- A new 13-lipoxygenase from Taxus media callus is functionally linked to paclitaxel biosynthesis.Scientific reports · 2025Article
- Plasma-activated water modulates taxanes production and phenylalanineammonia-lyase activity in Taxus baccata cell culture.PloS one · 2025Article
- Research on the Medicinal Chemistry and Pharmacology ofInternational journal of molecular sciences · 2024Review
- Heterologous expression of taxane genes confers resistance to fall armyworm in Nicotiana benthamiana.Plant cell reports · 2024Article
- Overexpression of BAPT and DBTNBT genes in Taxus baccata in vitro cultures to enhance the biotechnological production of paclitaxel.Plant biotechnology journal · 2024Article
- Insights into Metabolic Engineering of Bioactive Molecules inCurrent genomics · 2023Review
- Exploring the Interplay between Metabolic Pathways and Taxane Production in ElicitedPlants (Basel, Switzerland) · 2023Article
- Caleosin/peroxygenases: multifunctional proteins in plants.Annals of botany · 2023Review
- Switching cell fate by the actin-auxin oscillator in Taxus: cellular aspects of plant cell fermentation.Plant cell reports · 2022Article
- Insights into the control of taxane metabolism: Molecular, cellular, and metabolic changes induced by elicitation inFrontiers in plant science · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key messageOur paper describes the potential roles of lipid droplets of Taxus media cell suspension in the biosynthesis and secretion of paclitaxel and, therefore, highlights their involvement in improving its production. Paclitaxel (PTX) is a highly potent anticancer drug that is mainly produced using Taxus sp. cell suspension cultures. The main purpose of the current study is to characterize cellular LDs from T. media cell suspension with a particular focus on the biological connection of their associated proteins, the caleosins (CLOs), with the biosynthesis and secretion of PTX. A pure LD fraction obtained from T. media cells and characterized in terms of their proteome. Interestingly, the cellular LD in T. media sequester the PTX. This was confirmed in vitro, where about 96% of PTX (C
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.