Evidence map›Paper›PMID 34984343›Full record

ArticleCurrent research in physiology2022

Region-specific effects of antenatal/early postnatal hypothyroidism on endothelial NO-pathway activity in systemic circulation.

Dina K Gaynullina, Svetlana I Sofronova, Ekaterina K Selivanova, Anastasia A Shvetsova, Anna A Borzykh, Olga S Tarasova

Open access · goldAbstract read
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In one paragraph

Article in Current research in physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Dina K GaynullinaDepartment of Human and Animal Physiology, Faculty of Biology, M.V. Lomonosov Moscow State University, 119234, Moscow, Russia.
Svetlana I SofronovaDepartment of Human and Animal Physiology, Faculty of Biology, M.V. Lomonosov Moscow State University, 119234, Moscow, Russia.
Ekaterina K SelivanovaDepartment of Human and Animal Physiology, Faculty of Biology, M.V. Lomonosov Moscow State University, 119234, Moscow, Russia.
Anastasia A ShvetsovaDepartment of Human and Animal Physiology, Faculty of Biology, M.V. Lomonosov Moscow State University, 119234, Moscow, Russia.
Anna A BorzykhLaboratory of Exercise Physiology, State Research Center of the Russian Federation-Institute for Biomedical Problems, Russian Academy of Sciences, 123007, Moscow, Russia.
Olga S TarasovaDepartment of Human and Animal Physiology, Faculty of Biology, M.V. Lomonosov Moscow State University, 119234, Moscow, Russia.
Lomonosov Moscow State University · RURussian Academy of Sciences · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAntenatal/early postnatal hypothyroidism weakens NO-mediated anticontractile influence of endothelium in coronary arteries of adult rats, but it remains unclear whether this occurs in other vascular regions. We hypothesized that developmental thyroid deficiency is followed by region-specific changes in the endothelial NO-pathway activity in systemic vasculature. To explore this, we estimated the effects of antenatal/early postnatal hypothyroidism on NO-pathway activity and its potential local control mechanisms in rat mesenteric and skeletal muscle (sural) arteries.

methodsDams were treated with 6-propyl-2-thiouracil (PTU) in drinking water (0.0007%) during pregnancy and 2 weeks postpartum; control (CON) females received PTU-free water. Adult offspring (10-12-weeks) arteries were studied by wire myography, qPCR, and Western blotting.

resultsEndothelium removal or inhibition of NO-synthase with L-NNA augmented contractile responses to α

conclusionAntenatal/early postnatal hypothyroidism is followed by an increase in NO-mediated anticontractile influence in sural, but not in mesenteric arteries of adult animals. The diversity of hypothyroidism effects may be due to different alterations of local T3 synthesis/reception in different vascular beds.

Indexed as

Deiodinase 2Maternal hypothyroidismNitric oxideSmall arteriesThyroid hormone receptor α

Identifiers

PMID34984343
PMCPMC8692882
OpenAlexW4200283007

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.