Evidence map›Paper›PMID 34984327›Full record

ArticleiScience2022

PPARα and PPARγ activation is associated with pleural mesothelioma invasion but therapeutic inhibition is ineffective.

M Lizeth Orozco Morales, Catherine A Rinaldi, Emma de Jong, Sally M Lansley, Joel P A Gummer, Bence Olasz, Shabarinath Nambiar, Danika E Hope, Thomas H Casey, Y C Gary Lee and 12 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 8 institutions in 2 countries.

M Lizeth Orozco MoralesSchool of Biomedical Sciences, University of Western Australia, Crawley, WA 6009, Australia.
Catherine A RinaldiSchool of Biomedical Sciences, University of Western Australia, Crawley, WA 6009, Australia.
Emma de JongTelethon Kids Institute, University of Western Australia, West Perth, WA 6872, Australia.
Sally M LansleyInstitute for Respiratory Health, Nedlands, WA 6009, Australia.
Joel P A GummerSchool of Science, Department of Science, Edith Cowan University, Joondalup, WA 6027, Australia.
Bence OlaszSchool of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia.
Shabarinath NambiarSchool of Veterinary and Life Science, Murdoch University, Murdoch, WA 6150, Australia.
Danika E HopeSchool of Biomedical Sciences, University of Western Australia, Crawley, WA 6009, Australia.
Thomas H CaseySchool of Biomedical Sciences, University of Western Australia, Crawley, WA 6009, Australia.
Y C Gary LeeInstitute for Respiratory Health, Nedlands, WA 6009, Australia.
Connull LeslieDepartment of Anatomical Pathology, PathWest Laboratory Medicine, QEII Medical Centre, Nedlands, WA 6009, Australia.
Gareth NealonSchool of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia.
David M ShacklefordCentre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
Andrew K PowellCentre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia.
Marina GrimaldiIRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier 34090, France.
Patrick BalaguerIRCM, Institut de Recherche en Cancérologie de Montpellier, Montpellier 34090, France.
Rachael M ZemekTelethon Kids Institute, University of Western Australia, West Perth, WA 6872, Australia.
Anthony BoscoTelethon Kids Institute, University of Western Australia, West Perth, WA 6872, Australia.
Matthew J PiggottSchool of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia.
Alice VrielinkSchool of Molecular Sciences, University of Western Australia, Crawley, WA 6009, Australia.
Richard A LakeSchool of Biomedical Sciences, University of Western Australia, Crawley, WA 6009, Australia.
W Joost LesterhuisSchool of Biomedical Sciences, University of Western Australia, Crawley, WA 6009, Australia.
The University of Western Australia · AUThe Kids Research Institute Australia · AUInstitut de Recherche en Cancérologie de Montpellier · FRInstitute for Respiratory Health · AUMonash University · AUEdith Cowan University · AUMurdoch University · AUQueen Elizabeth II Medical Centre · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mesothelioma is a cancer that typically originates in the pleura of the lungs. It rapidly invades the surrounding tissues, causing pain and shortness of breath. We compared cell lines injected either subcutaneously or intrapleurally and found that only the latter resulted in invasive and rapid growth. Pleural tumors displayed a transcriptional signature consistent with increased activity of nuclear receptors PPARα and PPARγ and with an increased abundance of endogenous PPAR-activating ligands. We found that chemical probe GW6471 is a potent, dual PPARα/γ antagonist with anti-invasive and anti-proliferative activity

Indexed as

Biological sciencesMetabolomicsTranscriptomics

Identifiers

PMID34984327
PMCPMC8692993
OpenAlexW4200611702

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.