Evidence map›Paper›PMID 34984173›Full record

ArticleInterdisciplinary neurosurgery : Advanced techniques and case management2018

Predicting primary outcomes of brain tumor patients with advanced neuroimaging MRI measures.

Svyat Vergun, Josh I Suhonen, Veena A Nair, J S Kuo, M K Baskaya, Camille Garcia-Ramos, Elizabeth E Meyerand, Vivek Prabhakaran

Abstract read
In one paragraph

Article in Interdisciplinary neurosurgery : Advanced techniques and case management, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Svyat VergunDepartment of Medical Physics, University of Wisconsin-Madison, School of Medicine and Public Health, 1111 Highland Avenue, Madison, WI53792-3252, USA.
Josh I SuhonenDepartment of Radiology, University of Wisconsin-Madison, School of Medicine and Public Health, 600 Highland Avenue, Wisconsin Institutes for Medical Research (WIMR), Madison, WI 53705, USA.
Veena A NairDepartment of Radiology, University of Wisconsin-Madison, School of Medicine and Public Health, 600 Highland Avenue, Wisconsin Institutes for Medical Research (WIMR), Madison, WI 53705, USA.
J S KuoDepartment of Neurosurgery, University of Wisconsin-Madison, School of Medicine and Public Health, University of Wisconsin, Box 8660 Clinical Science Center, 600 Highland Ave, Madison, WI 53792, USA.
M K BaskayaDepartment of Neurosurgery, University of Wisconsin-Madison, School of Medicine and Public Health, University of Wisconsin, Box 8660 Clinical Science Center, 600 Highland Ave, Madison, WI 53792, USA.
Camille Garcia-RamosDepartment of Medical Physics, University of Wisconsin-Madison, School of Medicine and Public Health, 1111 Highland Avenue, Madison, WI53792-3252, USA.
Elizabeth E MeyerandDepartments of Biomedical Engineering University of Wisconsin-Madison, 1550 Engineering Dr, Madison, WI 53706, USA.
Vivek PrabhakaranDepartment of Radiology, Director of Functional Neuroimaging in Radiology, University of Wisconsin Madison, School of Medicine and Public Health, 600 Highland Avenue, Madison, WI 53792-3252, USA.

Funding

Institutional Clinical and Translational Science AwardUL1TR000427 · NCATS · UNIVERSITY OF WISCONSIN-MADISON · PI DREZNER, MARC KENNETH · 2012 to 2016
$32.2M
Microcirculation in Renovascular HypertensionR01HL095638 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI CHADE, ALEJANDRO ROBERTO · 2010 to 2021
$3.9M
Validating Resting State fMRI Derived Brain ConnectivityRC1MH090912 · NIMH · UNIVERSITY OF WISCONSIN-MADISON · PI MEYERAND, MARY E. · 2009 to 2010
$999k
Clinical Neuroengineering Training ProgramT32EB011434 · NIBIB · UNIVERSITY OF WISCONSIN-MADISON · PI MEYERAND, MARY E., PEARCE, ROBERT A · 2011 to 2015
$869k
Stroke PlasticityK23NS086852 · NINDS · UNIVERSITY OF WISCONSIN-MADISON · PI PRABHAKARAN, VIVEK · 2014 to 2017
$749k
Presurgical brain mapping with functional connectivity MRIR41NS081926 · NINDS · PRISM CLINICAL IMAGING INC. · PI DEYOE, EDGAR A · 2013 to 2013
$278k
NCATS NIH HHS UL1 TR000427NHLBI NIH HHS R01 HL095638NIBIB NIH HHS T32 EB011434NIMH NIH HHS RC1 MH090912NINDS NIH HHS K23 NS086852NINDS NIH HHS L30 NS066799NINDS NIH HHS R41 NS081926
6 · The paper itself

Abstract

backgroundAdvanced neuroimaging measures along with clinical variables acquired during standard imaging protocols provide a rich source of information for brain tumor patient treatment and management. Machine learning analysis has had much recent success in neuroimaging applications for normal and patient populations and has potential, specifically for brain tumor patient outcome prediction. The purpose of this work was to construct, using the current patient population distribution, a high accuracy predictor for brain tumor patient outcomes of mortality and morbidity (i.e., transient and persistent language and motor deficits). The clinical value offered is a statistical tool to help guide treatment and planning as well as an investigation of the influential factors of the disease process.

methodsResting state fMRI, diffusion tensor imaging, and task fMRI data in combination with clinical and demographic variables were used to represent the tumor patient population (n = 62; mean age = 51.2 yrs.) in a machine learning analysis in order to predict outcomes.

resultsA support vector machine classifier with a

conclusionsThis study showed that advanced neuroimaging data with machine learning methods can potentially predict patient outcomes and reveal influential factors driving the predictions.

Indexed as

DTIfMRIMachine-learningOutcome predictionTumor patients

Identifiers

PMID34984173
PMCPMC8722581

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.