Evidence map›Paper›PMID 34983920›Full record

ArticleAnnals of transplantation2022

Reconstruction of Separated Intrahepatic Ducts Using the Cystic and Common Hepatic Ducts in Right-Lobe Living-Donor Liver Transplantation: Experiences of Surgical Techniques, Biliary Complications, and Outcomes in a Single Institution.

Po-Jung Hsu, Hao-Chien Hung, Ching-Sung Lee, Kuang-Tse Pan, Jin-Chiao Lee, Yu-Chao Wang, Chih-Hsien Cheng, Tsung-Han Wu, Chen-Fang Lee, Hong-Shiue Chou and 3 more

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Article in Annals of transplantation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

13 authors.

Po-Jung HsuDepartment of General Surgery, Chang-Gung Memorial Hospital, Chang-Gung University, College of Medicine, Taoyuan, Taiwan.
Hao-Chien HungDepartment of General Surgery, Chang-Gung Memorial Hospital, Chang-Gung University, College of Medicine, Taoyuan, Taiwan.
Ching-Sung LeeDepartment of Gastroenterology, Chang-Gung Memorial Hospital, Chang-Gung University, College of Medicine, Taoyuan, Taiwan.
Kuang-Tse PanDepartment of Radiology, Chang-Gung Memorial Hospital, Chang-Gung University, College of Medicine, Taoyuan, Taiwan.
Jin-Chiao LeeDepartment of Gastroenterology, Chang-Gung Memorial Hospital, Chang-Gung University, College of Medicine, Taoyuan, Taiwan.
Yu-Chao WangDepartment of Gastroenterology, Chang-Gung Memorial Hospital, Chang-Gung University, College of Medicine, Taoyuan, Taiwan.
Chih-Hsien ChengDepartment of Gastroenterology, Chang-Gung Memorial Hospital, Chang-Gung University, College of Medicine, Taoyuan, Taiwan.
Tsung-Han WuDepartment of Gastroenterology, Chang-Gung Memorial Hospital, Chang-Gung University, College of Medicine, Taoyuan, Taiwan.
Chen-Fang LeeDepartment of Gastroenterology, Chang-Gung Memorial Hospital, Chang-Gung University, College of Medicine, Taoyuan, Taiwan.
Hong-Shiue ChouDepartment of Gastroenterology, Chang-Gung Memorial Hospital, Chang-Gung University, College of Medicine, Taoyuan, Taiwan.
Kun-Ming ChanDepartment of Gastroenterology, Chang-Gung Memorial Hospital, Chang-Gung University, College of Medicine, Taoyuan, Taiwan.
Wei-Chen LeeDepartment of Gastroenterology, Chang-Gung Memorial Hospital, Chang-Gung University, College of Medicine, Taoyuan, Taiwan.
Ting-Jung WuDepartment of General Surgery, Chang-Gung Memorial Hospital, Chang-Gung University, College of Medicine, Taoyuan, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND Duct-to-duct biliary reconstruction has been increasingly used in living-donor liver transplantation. Information regarding dual duct-to-duct biliary anastomoses is limited. We present the largest case series to date on the use of the cystic and common hepatic ducts as dual-ductal anastomosis, along with long-term follow-up results. MATERIAL AND METHODS In this study, 740 patients underwent right-lobe living-donor liver transplantation; 56 of them were documented as dual-ductal anastomoses. We analyzed recipient and donor characteristics, surgical procedures, appearance of biliary complications, corresponding interventions, and long-term biliary outcomes. RESULTS Cystic and common hepatic ducts were utilized in 56 cases of dual-ductal biliary reconstruction, which we categorized into 2 types: A (78.6%), in which the right anterior intrahepatic duct was anastomosed to the common hepatic duct and the right posterior intrahepatic duct to the cystic duct; and B (21.4%), which was the reverse of A. After a median follow-up period of 46.4 months, 23 patients (41.1%) experienced complications, including biliary leakage and biliary stricture. However, after aggressive intervention (patent biliary anastomosis in most of them), 50 of 56 patients (89.3%) had patent biliary anastomosis and restored normal liver function at the end of follow-up. A small graft (graft-to-recipient weight ratio <0.9%) was the only predictor of biliary complications after multivariate analysis. CONCLUSIONS Dual-ductal biliary reconstruction in adult right-lobe living-donor liver transplantation is challenging but feasible. Our findings support the use of the cystic duct for reconstruction in selected patients. Good long-term results can be achieved with adequate management of patients with biliary complications.

Indexed as

Liver TransplantationAdultAnastomosis, SurgicalBile DuctsHepatic Duct, CommonHumansLiverLiving Donors

Identifiers

PMID34983920
PMCPMC8744362

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.