ArticleProceedings of the National Academy of Sciences of the United States of America2022
Association of improved air quality with lower dementia risk in older women.
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In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 4 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 4 pooled it
4.0field-weighted citation impact, top 5% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 4 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- A systematic review with a Burden of Proof meta-analysis of health effects of long-term ambient fine particulate matter (PMNature aging · 2025Pooled it
- Geospatial analysis of environmental atmospheric risk factors in neurodegenerative diseases: a systematic review update.Systematic reviews · 2024Pooled it
- Beneficial Effect of Societal Factors on APOE-ε2 and ε4 Carriers' Brain Health: A Systematic Review.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Pooled it
- Ambient air pollution and clinical dementia: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2023Pooled it
- Aging in a highly polluted world: challenges and solutions to prevent Alzheimer's disease.Archives of toxicology · 2026Review
- Air Pollution and Alzheimer's Disease: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2026Review
- A critical review of potential modifiers of air pollutant associations with dementia and related outcomes.Neurotoxicology · 2026Review
- Associations between air pollution and markers of neuroinflammation, synaptic dysfunction and core Alzheimer's disease pathology vary by APOE genotype.Neurotoxicity research · 2026Article
- Integrating the physical environment into Alzheimer's disease and Alzheimer's disease related dementias research: A Gateway Exposome Coordinating Center (GECC) agenda on gaps and priorities.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Racial and ethnic differences in the impact of air pollution on the risk of Alzheimer's disease and related dementias in the Multiethnic Cohort Study.Environment international · 2026Article
- The sex-specific association between long-term PM2.5 exposure and incident dementia in community-dwelling older adults in Australia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The impact of nutritional, environmental, and lifestyle factors on neurological disorders: therapeutic implications and mechanistic insights.Frontiers in pharmacology · 2026Review
- Estimating daily air quality exposure of the aging and dementia population.Journal of Alzheimer's disease : JAD · 2025Article
- Long-term exposure to air pollution and risk of dementia among older individuals of a Danish nationwide administrative cohort.Environment international · 2025Article
- Pathways to the Brain: Impact of Fine Particulate Matter Components on the Central Nervous System.Antioxidants (Basel, Switzerland) · 2025Review
- Identifying air quality monitoring deserts in the United States.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Life-course exposure to air pollution and the risk of dementia in the Lothian Birth Cohort 1936.Environmental epidemiology (Philadelphia, Pa.) · 2025Article
- The Role of Genetic, Environmental, and Dietary Factors in Alzheimer's Disease: A Narrative Review.International journal of molecular sciences · 2025Review
- Air Pollution as an Environmental Risk Factor for Alzheimer's Disease and Related Dementias.Medical research archives · 2024Article
- Examining the Relationships Between Indoor Environmental Quality Parameters Pertaining to Light, Noise, Temperature, and Humidity and the Behavioral and Psychological Symptoms of People Living With Dementia: Scoping Review.Interactive journal of medical research · 2024Article
Corrections and comments
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Authors and funding
16 authors at 7 institutions in 1 country.
Xinhui WangDepartment of Neurology, University of Southern California, Los Angeles, CA 90033.ORCID 0000-0002-1180-4624
Diana YounanDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA 90032; dyounan@usc.edu jcchen@usc.edu.ORCID 0000-0003-1933-8098
Joshua MillsteinDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA 90032.ORCID 0000-0001-7961-8943
Andrew J PetkusDepartment of Neurology, University of Southern California, Los Angeles, CA 90033.
Erika GarciaDepartment of Population and Public Health Sciences, University of Southern California, Los Angeles, CA 90032.ORCID 0000-0003-1540-9805
Daniel P BeaversDepartment of Biostatistics and Data Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157.
Mark A EspelandDepartment of Biostatistics and Data Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157.ORCID 0000-0002-3711-1949
Helena C ChuiDepartment of Neurology, University of Southern California, Los Angeles, CA 90033.
Susan M ResnickLaboratory of Behavioral Neuroscience, National Institute on Aging, Baltimore, MD 21224.
Margaret GatzCenter for Economic and Social Research, University of Southern California, Los Angeles, CA 90089.ORCID 0000-0002-1071-9970
Joel D KaufmanDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195.ORCID 0000-0003-4174-9037
Gregory A WelleniusDepartment of Environmental Health, Boston University, Boston, MA 02215.
Eric A WhitselDepartment of Epidemiology, UNC Gillings School of Global Public Health, Chapel Hill, NC 27599.ORCID 0000-0003-4843-3641
JoAnn E MansonDepartment of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115.ORCID 0000-0002-9426-7595
Stephen R RappDepartment of Psychiatry and Behavioral Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157.ORCID 0000-0002-9766-3104
Jiu-Chiuan ChenDepartment of Neurology, University of Southern California, Los Angeles, CA 90033; dyounan@usc.edu jcchen@usc.edu.
University of Southern California · USWake Forest University · USBoston University · USBrigham and Women's Hospital · USNational Institute on Aging · USUniversity of North Carolina Health Care · USUniversity of Washington · US
Funding
Translational Research Support CoreP30ES007048 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ROB S MCCONNELL · 1996 to 2026
$46.4MXENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Sheela Sathyanarayana · 1995 to 2026
$42.5MVASCULAR RISK AND COGNITIVE STATUS IN A LATINO POPULATIONP50AG005142 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BRASKIE, MEREDITH NICOLE · 1985 to 2019
$41.0MUNC-CH CENTER FOR ENVIRONMENTAL HEALTH &SUSCEPTIBILITYP30ES010126 · NIEHS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Stephanie Engel · 2001 to 2026
$36.3MUSCADRC Diversity Supplement PachicanoP30AG066530 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI HELENA Chang CHUI, ARTHUR W TOGA · 2020 to 2026
$27.8MWake Forest University School of Medicine Alzheimer's Disease Research CenterP30AG072947 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI SUZANNE CRAFT · 2021 to 2026
$24.3MWake Forest Alzheimer's Disease Core CenterP30AG049638 · NIA · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ESPELAND, MARK ANDREW · 2016 to 2020
$12.2MUrban Air Pollution and Pathological Brain Aging: A Nationwide Twin Study in MenP01AG055367 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN, FINCH, CALEB E · 2018 to 2022
$11.5MAlzheimer's Disease & Related Dementias: Geography, Environments, and MechanismsRF1AG054068 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN · 2016 to 2016
$4.1MEnvironmental Determinants of Pathological Brain Aging in WHI Memory StudiesR01ES025888 · NIEHS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN, KAUFMAN, JOEL DANIEL · 2016 to 2020
$3.2MEnvironmental Determinants of Cognitive Aging in the WHI Memory StudyR01AG033078 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI CHEN, JIU-CHIUAN · 2011 to 2014
$2.6MWomen's Health Initiative Suite of Studies - Extension StudyZIAAG000190 · NIA · NATIONAL INSTITUTE ON AGING · PI RESNICK, SUSAN · 2009 to 2024
$1.5MNHLBI NIH HHS HHSN268201600001CNHLBI NIH HHS HHSN268201600002CNHLBI NIH HHS HHSN268201600003CNHLBI NIH HHS HHSN268201600004CNHLBI NIH HHS HHSN268201600018CNIA NIH HHS P01 AG055367NIA NIH HHS P30 AG049638NIA NIH HHS P30 AG066530NIA NIH HHS P30 AG072947NIA NIH HHS P50 AG005142NIA NIH HHS R01 AG033078NIA NIH HHS RF1 AG054068NIEHS NIH HHS P30 ES007033NIEHS NIH HHS P30 ES007048NIEHS NIH HHS P30 ES010126NIEHS NIH HHS R01 ES025888
Abstract
Late-life ambient air pollution is a risk factor for brain aging, but it remains unknown if improved air quality (AQ) lowers dementia risk. We studied a geographically diverse cohort of older women dementia free at baseline in 2008 to 2012 (
Indexed as
AgedAged, 80 and overAir PollutantsAir PollutionCohort StudiesDementiaEnvironmental ExposureFemaleHumansIncidenceNitrogen DioxideParticulate MatterProportional Hazards ModelsRisk FactorsAir PollutantsNitrogen DioxideParticulate Matterair pollutionair qualitydementiaepidemiologyincidence
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LicenceCC BY-NC-ND
Read underepoch 390
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.