Evidence map›Paper›PMID 34983855›Full record

ArticleJournal of medical ethics2023

Ethical analysis examining the prioritisation of living donor transplantation in times of healthcare rationing.

Sanjay Kulkarni, Andrew Flescher, Mahwish Ahmad, George Bayliss, David Bearl, Lynsey Biondi, Earnest Davis, Roshan George, Elisa Gordon, Tania Lyons and 2 more

Open access · hybridAbstract read
In one paragraph

Article in Journal of medical ethics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 1 country.

Sanjay KulkarniDepartment of Surgery, Yale University School of Medicine, New Haven, Connecticut, USA sanjay.kulkarni@yale.edu.ORCID 0000-0002-0835-7907
Andrew FlescherDepartment of English, Stony Brook University, Stony Brook, New York, USA.
Mahwish AhmadCenter for Bioethics, Cleveland Clinic Foundation, Cleveland, Ohio, USA.
George BaylissDepartment of Medicine, Brown Univeristy School of Medicine, Providence, Rhode Island, USA.
David BearlDepartment of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA.
Lynsey BiondiDepartment of Surgery, West Virginia University School of Medicine, Morgantown, West Virginia, USA.
Earnest DavisUNOS Ethics Committee, Richmond, Virginia, USA.
Roshan GeorgeDepartment of Pediatrics, Emory Univeristy School of Medicine, Atlanta, Georgia, USA.
Elisa GordonDepartment of Surgery, Northwestern University School of Medicine, Chicago, Illinois, USA.
Tania LyonsUNOS Ethics Committee, Richmond, Virginia, USA.
Aaron WightmanDepartment of Pediatrics, University of Washington School of Medicine, Seattle, Washington, USA.
Keren LadinDepartment of Community Health, Tufts University, Medford, Massachusetts, USA.ORCID 0000-0002-4310-8260
Brown University · USCleveland Clinic · USEmory University · USNorthwestern University · USStony Brook University · USTufts University · USUniversity of Washington · USVanderbilt University · USWest Virginia University · USYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

The transplant community has faced unprecedented challenges balancing risks of performing living donor transplants during the COVID-19 pandemic with harms of temporarily suspending these procedures. Decisions regarding postponement of living donation stem from its designation as an elective procedure, this despite that the Centers for Medicare and Medicaid Services categorise transplant procedures as tier 3b (high medical urgency-do not postpone). In times of severe resource constraints, health systems may be operating under crisis or contingency standards of care. In this manuscript, the United Network for Organ Sharing Ethics Workgroup explores prioritisation of living donation where health systems operate under contingency standards of care and provide a framework with recommendations to the transplant community on how to approach living donation in these circumstances.To guide the transplant community in future decisions, this analysis suggests that: (1) living donor transplants represent an important option for individuals with end-stage liver and kidney disease and should not be suspended uniformly under contingency standards, (2) exposure risk to SARS-CoV-2 should be balanced with other risks, such as exposure risks at dialysis centres. Because many of these risks are not quantifiable, donors and recipients should be included in discussions on what constitutes acceptable risk, (3) transplant hospitals should strive to maintain a critical transplant workforce and avoid diverting expertise, which could negatively impact patient preparedness for transplant, (4) transplant hospitals should consider implementing protocols to ensure early detection of SARS-CoV-2 infections and discuss these measures with donors and recipients in a process of shared decision-making.

Indexed as

COVID-19Tissue and Organ ProcurementAgedEthical AnalysisHealth Care RationingHumansLiving DonorsMedicarePandemicsSARS-CoV-2United Statesallocation of health care resourcesclinical ethicsethics

Identifiers

PMID34983855
PMCPMC10314075
OpenAlexW4206365783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.