ArticleProceedings of the National Academy of Sciences of the United States of America2022
Temporal-spectral signaling of sensory information and expectations in the cerebral processing of pain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 55 citations in OpenAlex.
- Beware of What You Expect? A Partial Replication Study on the Behavioral and Psychophysiological Effects of Negative Expectations on Mechanical Hypersensitivity.Psychophysiology · 2026Trial
- Neurofeedback and attention modulate somatosensory alpha oscillations but not pain perception.PLoS biology · 2025Trial
- Article
- Contextual Modulation of Fronto-Central, Parietal, and Global Peak Alpha Frequency.European journal of pain (London, England) · 2026Article
- EEG-based clustering shows distinct separation of chronic pain patients before spinal cord stimulation surgery.NeuroImage · 2026Article
- Pain Expectation in Individuals With High Autistic Traits: Decision-Evaluation Processes and Oxytocin Modulation.Annals of the New York Academy of Sciences · 2026Article
- Brain rhythms of depression: A predictive processing perspective.Trends in neurosciences · 2026Review
- Neural encoding of pain is robust within but unstable between individuals.PLoS biology · 2026Article
- Temporal predictions shape somatosensory perception.Nature communications · 2026Article
- Dynamic expectation strength and precision shape human pain perception through shared and dissociable α-oscillatory mechanisms.PLoS biology · 2026Article
- Article
- AQMFB-DWT: A Preprocessing Technique for Removing Blink Artifacts Before Extracting Pain-evoked Potential EEG.Neuroscience bulletin · 2025Article
- EEG Correlates of the Influence of Somatosensory Input, Expectations and Trait-Like Bias on Pain Perception.European journal of pain (London, England) · 2025Article
- Investigating the Influence of Experimentally Induced Secondary Hyperalgesia on Pain Prediction Error Encoding in Healthy Individuals: A Novel Virtual Reality Protocol.European journal of pain (London, England) · 2025Article
- Neural variability reliably encodes interindividual differences in the perception of pain intensity.PLoS biology · 2025Article
- A comprehensive EEG dataset of laser-evoked potentials for pain research.Scientific data · 2025Article
- Pre-stimulus beta power mediates explicit and implicit perceptual biases in distinct cortical areas.Communications psychology · 2025Article
- Temporal changes in cortical sensory processing during the transition from acute to chronic low back pain.Pain reports · 2025Article
- EEG oscillations reveal neuroplastic changes in pain processing associated with long-term meditation.Scientific reports · 2025Article
- Physiological Sensor Modality Sensitivity Test for Pain Intensity Classification in Quantitative Sensory Testing.Sensors (Basel, Switzerland) · 2025Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The perception of pain is shaped by somatosensory information about threat. However, pain is also influenced by an individual's expectations. Such expectations can result in clinically relevant modulations and abnormalities of pain. In the brain, sensory information, expectations (predictions), and discrepancies thereof (prediction errors) are signaled by an extended network of brain areas which generate evoked potentials and oscillatory responses at different latencies and frequencies. However, a comprehensive picture of how evoked and oscillatory brain responses signal sensory information, predictions, and prediction errors in the processing of pain is lacking so far. Here, we therefore applied brief painful stimuli to 48 healthy human participants and independently modulated sensory information (stimulus intensity) and expectations of pain intensity while measuring brain activity using electroencephalography (EEG). Pain ratings confirmed that pain intensity was shaped by both sensory information and expectations. In contrast, Bayesian analyses revealed that stimulus-induced EEG responses at different latencies (the N1, N2, and P2 components) and frequencies (alpha, beta, and gamma oscillations) were shaped by sensory information but not by expectations. Expectations, however, shaped alpha and beta oscillations before the painful stimuli. These findings indicate that commonly analyzed EEG responses to painful stimuli are more involved in signaling sensory information than in signaling expectations or mismatches of sensory information and expectations. Moreover, they indicate that the effects of expectations on pain are served by brain mechanisms which differ from those conveying effects of sensory information on pain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.