Evidence map›Paper›PMID 34983773›Full record

ArticleBMJ open2022

Exploring hepatitis C virus testing and treatment engagement over time in Melbourne, Australia: a study protocol for a longitudinal cohort study (EC-Experience Cohort study).

Daniel O'Keefe, J Gunn, Kathleen Ryan, Filip Djordjevic, Phoebe Kerr, Judy Gold, Imogen Elsum, Chloe Layton, Kico Chan, Paul Dietze and 5 more

Open access · goldAbstract read
In one paragraph

Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Daniel O'KeefeDisease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia daniel.okeefe@burnet.edu.au.ORCID 0000-0001-6799-2372
J GunnDisease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia.
Kathleen RyanDisease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia.
Filip DjordjevicDisease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia.
Phoebe KerrDisease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia.
Judy GoldDisease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia.
Imogen ElsumDisease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia.
Chloe LaytonDisease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia.
Kico ChanDisease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia.
Paul DietzeDisease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia.
Peter HiggsDisease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia.
Joseph DoyleDisease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia.
Mark A StoovéDisease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia.
Margaret HellardDisease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia.
A E PedranaDisease Elimination Program, Burnet Institute, Melbourne, Victoria, Australia.
Burnet Institute · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe advent of direct acting antiviral therapy for hepatitis C virus (HCV) means the elimination of HCV is possible but requires sustained effort to achieve. Between 2016 and 2019, 44% of those living with HCV were treated in Australia. However, treatment uptake has declined significantly. In Australia, people who inject drugs (PWID) are the population most at risk of HCV acquisition. Eliminating HCV in Australia will require nuanced understanding of the barriers to HCV treatment experienced by PWID and tailored interventions to address these barriers. The EC-Experience Cohort study aims to explore the barriers and enablers reported by PWID to engagement in HCV care. METHODS AND ANALYSIS: The EC-Experience Cohort study is a prospective cohort of PWID, established in Melbourne, Australia in 2018. Participants are assigned into three study groups: (1) those not currently engaged in HCV testing; (2) those diagnosed with HCV but not currently engaged in treatment and (3) those completed treatment. Participants complete a total of four interviews every 6 months across an 18-month study period. Predictors of experience of key outcome events along the HCV care cascade will be explored over time. ETHICS AND DISSEMINATION: Ethical approval for the EC-Experience Cohort study was obtained by the Alfred Hospital Ethics Committee in Melbourne, Australia (Project Number: HREC/16/Alfred/164). All eligible participants are assessed for capacity to consent and partake in a thorough informed consent process. Results from the EC-Experience Cohort study will be disseminated via national and international scientific and public health conferences and peer-reviewed journal publications. Data from the EC-Experience Cohort study will improve the current understanding of the barriers to HCV care for PWID and guide the tailoring of service provision for specific subgroups. Understanding the barriers and how to increase engagement in care of PWID is critical to achieve HCV elimination goals.

Indexed as

Hepatitis CHepatitis C, ChronicSubstance Abuse, IntravenousAntiviral AgentsAustraliaCohort StudiesHepacivirusHumansLongitudinal StudiesProspective StudiesAntiviral Agentsprimary careprotocols & guidelinespublic health

Identifiers

PMID34983773
PMCPMC8728403
OpenAlexW4205347070

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.