ArticleBMJ open2022
Biological and clinical correlates of the patient health questionnaire-9: exploratory cross-sectional analyses of the baseline health study.
Article in BMJ open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03154346 (Project Baseline Health Study), which is not on this map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Project Baseline Health Study
Who cites it
6 citing papers in PubMed.
- Cardiorenal Syndrome and Depressive Symptoms: Exploring the Mood-Kidney Link With Heart Failure Risk in a Post-hoc Analysis of SPRINT.Kidney medicine · 2026Article
- Is there a mental health diagnostic crisis in primary care? Current research practices in global mental health cannot answer that question.Epidemiology and psychiatric sciences · 2025Article
- Resting Heart Rate and Associations With Clinical Measures From the Project Baseline Health Study: Observational Study.Journal of medical Internet research · 2024Observational
- Identifying characteristics and clinical conditions associated with hand grip strength in adults: the Project Baseline Health Study.Scientific reports · 2024Article
- Identifying a stable and generalizable factor structure of major depressive disorder across three large longitudinal cohorts.Psychiatry research · 2024Article
- Factors associated with lower quarter performance-based balance and strength tests: a cross-sectional analysis from the project baseline health study.Frontiers in sports and active living · 2024Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesWe assessed the relationship between the Patient Health Questionnaire-9 (PHQ-9) at intake and other measurements intended to assess biological factors, markers of disease and health status. DESIGN, SETTING AND
participantsWe performed a cross-sectional analysis of 2365 participants from the Baseline Health Study, a prospective cohort of adults selected to represent major demographic groups in the USA. Participants underwent deep phenotyping on demographic, clinical, laboratory, functional and imaging findings. IMPORTANCE: Despite extensive research on the clinical implications of the PHQ-9, data are limited on the relationship between PHQ-9 scores and other measures of health and disease; we sought to better understand this relationship.
interventionsNone. MAIN OUTCOMES AND MEASURES: Cross-sectional measures of medical illnesses, gait, balance strength, activities of daily living, imaging and laboratory tests.
resultsCompared with lower PHQ-9 scores, higher scores were associated with female sex (46.9%-66.7%), younger participants (53.6-42.4 years) and compromised physical status (higher resting heart rates (65 vs 75 bpm), larger body mass index (26.5-30 kg/m
conclusionsOur study highlights how: (1) even subthreshold depressive symptoms (measured by PHQ-9) may be indicative of several individual- and population-level concerns that demand more attention; and (2) depression should be considered a comorbidity in common disease. TRIAL REGISTRATION NUMBER: NCT03154346.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.