ReviewParasites & vectors2022
Vector microbiota manipulation by host antibodies: the forgotten strategy to develop transmission-blocking vaccines.
Review in Parasites & vectors, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 59 citations in OpenAlex.
- Comparative tissue-specific microbiome analyses identify keystone endosymbionts shaping pathogen interactions in dromedary camel ticks.BMC microbiology · 2026Article
- Microbiota-immune crosstalk in livestock: implications for tick-borne disease control.Frontiers in immunology · 2026Review
- Holobiont-holobiont interactions across host-ectoparasite systems.Parasites & vectors · 2025Review
- Effects of Live and Peptide-Based Antimicrobiota Vaccines onPathogens (Basel, Switzerland) · 2025Article
- Article
- The first direct detection of spotted fever group Rickettsia spp. diversity in ticks from Ningxia, northwestern China.PLoS neglected tropical diseases · 2025Article
- Why the Jenner/Pasteur paradigm is insufficient for controlling vector-borne diseases and the role of microbiota-mediated interactions.Current research in parasitology & vector-borne diseases · 2025Review
- The interplay between species and locations shapes vector fleas microbial communities in plague foci: pathogens rather than symbionts?Frontiers in cellular and infection microbiology · 2025Article
- Disruption of bacterial interactions and community assembly in Babesia-infected Haemaphysalis longicornis following antibiotic treatment.BMC microbiology · 2024Article
- Gut membrane proteins as candidate antigens for immunization of mice against the tick Amblyomma sculptum.Vaccine · 2024Article
- Evolution of tick vaccinology.Parasitology · 2024Review
- Guild Dynamics and Pathogen Interactions inTransboundary and emerging diseases · 2024Article
- Influence of microbiota-driven natural antibodies on dengue transmission.Frontiers in immunology · 2024Article
- Adiponectin in the mammalian host influences ticks' acquisition of the Lyme disease pathogen Borrelia.PLoS biology · 2023Article
- Alternative and Complementary Approaches to Consider for EffectivePathogens (Basel, Switzerland) · 2023Article
- Microbiota in disease-transmitting vectors.Nature reviews. Microbiology · 2023Review
- Microbiota perturbation by anti-microbiota vaccine reduces the colonization of Borrelia afzelii in Ixodes ricinus.Microbiome · 2023Article
- Comparison of salivary gland and midgut microbiome in the soft ticksFrontiers in microbiology · 2023Article
- Evolutionary consequences of vector-borne transmission: how using vectors shapes host, vector and pathogen evolution.Parasitology · 2022Review
- Rickettsia helvetica infection is associated with microbiome modulation in Ixodes ricinus collected from humans in Serbia.Scientific reports · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 8 institutions in 5 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Human and animal pathogens that are transmitted by arthropods are a global concern, particularly those vectored by ticks (e.g. Borrelia burgdorferi and tick-borne encephalitis virus) and mosquitoes (e.g. malaria and dengue virus). Breaking the circulation of pathogens in permanent foci by controlling vectors using acaricide-based approaches is threatened by the selection of acaricide resistance in vector populations, poor management practices and relaxing of control measures. Alternative strategies that can reduce vector populations and/or vector-mediated transmission are encouraged worldwide. In recent years, it has become clear that arthropod-associated microbiota are involved in many aspects of host physiology and vector competence, prompting research into vector microbiota manipulation. Here, we review how increased knowledge of microbial ecology and vector-host interactions is driving the emergence of new concepts and tools for vector and pathogen control. We focus on the immune functions of host antibodies taken in the blood meal as they can target pathogens and microbiota bacteria within hematophagous arthropods. Anti-microbiota vaccines are presented as a tool to manipulate the vector microbiota and interfere with the development of pathogens within their vectors. Since the importance of some bacterial taxa for colonization of vector-borne pathogens is well known, the disruption of the vector microbiota by host antibodies opens the possibility to develop novel transmission-blocking vaccines.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.