Evidence map›Paper›PMID 34983597›Full record

ArticleCritical care (London, England)2022

Respiratory effects of lung recruitment maneuvers depend on the recruitment-to-inflation ratio in patients with COVID-19-related acute respiratory distress syndrome.

Yoann Zerbib, Alexis Lambour, Julien Maizel, Loay Kontar, Bertrand De Cagny, Thierry Soupison, Thomas Bradier, Michel Slama, Clément Brault

Abstract read
In one paragraph

Article in Critical care (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Yoann ZerbibIntensive Care Department, CHU Amiens-Picardie, 1 Rue du Professeur Christian Cabrol, 80000, Amiens, France.
Alexis LambourIntensive Care Department, CHU Amiens-Picardie, 1 Rue du Professeur Christian Cabrol, 80000, Amiens, France.
Julien MaizelIntensive Care Department, CHU Amiens-Picardie, 1 Rue du Professeur Christian Cabrol, 80000, Amiens, France.
Loay KontarIntensive Care Department, CHU Amiens-Picardie, 1 Rue du Professeur Christian Cabrol, 80000, Amiens, France.
Bertrand De CagnyIntensive Care Department, CHU Amiens-Picardie, 1 Rue du Professeur Christian Cabrol, 80000, Amiens, France.
Thierry SoupisonIntensive Care Department, CHU Amiens-Picardie, 1 Rue du Professeur Christian Cabrol, 80000, Amiens, France.
Thomas BradierIntensive Care Department, CHU Amiens-Picardie, 1 Rue du Professeur Christian Cabrol, 80000, Amiens, France.
Michel SlamaIntensive Care Department, CHU Amiens-Picardie, 1 Rue du Professeur Christian Cabrol, 80000, Amiens, France.
Clément BraultIntensive Care Department, CHU Amiens-Picardie, 1 Rue du Professeur Christian Cabrol, 80000, Amiens, France. brault.clement@chu-amiens.fr.ORCID 0000-0001-6210-2270

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn the context of acute respiratory distress syndrome (ARDS), the response to lung recruitment maneuvers (LRMs) varies considerably from one patient to another and so is difficult to predict. The aim of the study was to determine whether or not the recruitment-to-inflation (R/I) ratio could differentiate between patients according to the change in lung mechanics during the LRM.

methodsWe evaluated the changes in gas exchange and respiratory mechanics induced by a stepwise LRM at a constant driving pressure of 15 cmH

resultsWe included 30 patients with moderate-to-severe ARDS and a median [interquartile range] R/I ratio of 0.62 [0.42-0.83]. After the LRM, patients with high recruitability (R/I ratio ≥ 0.62) presented an improvement in the P

conclusionAfter the LRM, patients with high recruitability presented a significant increase in respiratory system compliance (indicating a gain in ventilated area), while those with low recruitability presented a decrease in pulse pressure suggesting a drop in cardiac output and therefore in intrapulmonary shunt.

Indexed as

COVID-19LungRespiratory Distress SyndromeHumansPositive-Pressure RespirationSARS-CoV-2Acute respiratory distress syndromeMechanical ventilationRecruitabilityRecruitment maneuverRespiratory mechanics

Identifiers

PMID34983597
PMCPMC8727044

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.