Evidence map›Paper›PMID 34983560›Full record

ArticleJournal of nanobiotechnology2022

pH-switchable nanozyme cascade catalysis: a strategy for spatial-temporal modulation of pathological wound microenvironment to rescue stalled healing in diabetic ulcer.

Xuancheng Du, Bingqing Jia, Weijie Wang, Chengmei Zhang, Xiangdong Liu, Yuanyuan Qu, Mingwen Zhao, Weifeng Li, Yanmei Yang, Yong-Qiang Li

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  5. Article
  6. Recent Advances in Nanozymes Toward Diabetic Foot Ulcers.International journal of nanomedicine · 2026
    Review
  7. Review
  8. Article
  9. Biofilm-Responsive Nanoplatforms for Infected Wound Reconstruction.International journal of nanomedicine · 2026
    Review
  10. Article
  11. Article
  12. Review
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xuancheng Du *Institute of Advanced Interdisciplinary Science, School of Physics, Shandong University, Jinan, 250100, China.
Bingqing Jia *Institute of Advanced Interdisciplinary Science, School of Physics, Shandong University, Jinan, 250100, China.
Weijie WangInstitute of Advanced Interdisciplinary Science, School of Physics, Shandong University, Jinan, 250100, China.
Chengmei ZhangLaboratory Animal Center of Shandong University, Jinan, 250012, China.
Xiangdong LiuInstitute of Advanced Interdisciplinary Science, School of Physics, Shandong University, Jinan, 250100, China.
Yuanyuan QuInstitute of Advanced Interdisciplinary Science, School of Physics, Shandong University, Jinan, 250100, China.
Mingwen ZhaoInstitute of Advanced Interdisciplinary Science, School of Physics, Shandong University, Jinan, 250100, China.
Weifeng LiInstitute of Advanced Interdisciplinary Science, School of Physics, Shandong University, Jinan, 250100, China.
Yanmei YangCollege of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan, 250014, China. yym@sdnu.edu.cn.
Yong-Qiang LiInstitute of Advanced Interdisciplinary Science, School of Physics, Shandong University, Jinan, 250100, China. yqli@sdu.edu.cn.ORCID http://orcid.org/0000-0003-1551-3020

Funding

National Natural Science Foundation of China 21628201National Natural Science Foundation of China 31500802Natural Science Foundation of Jiangsu Province BK20190097Taishan Scholars Program for Young Expert of Shandong Province tsqn201909021
6 · The paper itself

Abstract

The management of diabetic ulcer (DU) to rescue stalled wound healing remains a paramount clinical challenge due to the spatially and temporally coupled pathological wound microenvironment that features hyperglycemia, biofilm infection, hypoxia and excessive oxidative stress. Here we present a pH-switchable nanozyme cascade catalysis (PNCC) strategy for spatial-temporal modulation of pathological wound microenvironment to rescue stalled healing in DU. The PNCC is demonstrated by employing the nanozyme of clinically approved iron oxide nanoparticles coated with a shell of glucose oxidase (Fe

Indexed as

Diabetes Mellitus, ExperimentalNanostructuresUlcerAnimalsBiofilmsCatalysisCellular MicroenvironmentDisease Models, AnimalHydrogen-Ion ConcentrationMiceNanomedicineWound HealingBiofilm eradicationCascade catalysisDiabetic ulcerNanozymePathological microenvironment modulation

Identifiers

PMID34983560
PMCPMC8725300

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.