Evidence map›Paper›PMID 34983491›Full record

ArticleBMC biology2022

Co-option of the limb patterning program in cephalopod eye development.

Stephanie Neal, Kyle J McCulloch, Francesca R Napoli, Christina M Daly, James H Coleman, Kristen M Koenig

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
10.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Stephanie Neal *John Harvard Distinguished Science Fellowship Program, Harvard University, Cambridge, MA, 02138, USA.
Kyle J McCulloch *John Harvard Distinguished Science Fellowship Program, Harvard University, Cambridge, MA, 02138, USA.
Francesca R NapoliJohn Harvard Distinguished Science Fellowship Program, Harvard University, Cambridge, MA, 02138, USA.
Christina M DalyJohn Harvard Distinguished Science Fellowship Program, Harvard University, Cambridge, MA, 02138, USA.
James H ColemanJohn Harvard Distinguished Science Fellowship Program, Harvard University, Cambridge, MA, 02138, USA.
Kristen M KoenigJohn Harvard Distinguished Science Fellowship Program, Harvard University, Cambridge, MA, 02138, USA. kmkoenig@fas.harvard.edu.ORCID 0000-0001-6093-2262
Harvard University · US

Funding

Investigating Organ Formation and the Emergence of Complexity in the Visual System Using Comparative Developmental ApproachesDP5OD023111 · OD · HARVARD UNIVERSITY · PI KOENIG, KRISTEN MARIE · 2016 to 2020
$2.1M
NIH HHS DP5 OD023111
6 · The paper itself

Abstract

backgroundAcross the Metazoa, similar genetic programs are found in the development of analogous, independently evolved, morphological features. The functional significance of this reuse and the underlying mechanisms of co-option remain unclear. Cephalopods have evolved a highly acute visual system with a cup-shaped retina and a novel refractive lens in the anterior, important for a number of sophisticated behaviors including predation, mating, and camouflage. Almost nothing is known about the molecular-genetics of lens development in the cephalopod.

resultsHere we identify the co-option of the canonical bilaterian limb patterning program during cephalopod lens development, a functionally unrelated structure. We show radial expression of transcription factors SP6-9/sp1, Dlx/dll, Pbx/exd, Meis/hth, and a Prdl homolog in the squid Doryteuthis pealeii, similar to expression required in Drosophila limb development. We assess the role of Wnt signaling in the cephalopod lens, a positive regulator in the developing Drosophila limb, and find the regulatory relationship reversed, with ectopic Wnt signaling leading to lens loss.

conclusionThis regulatory divergence suggests that duplication of SP6-9 in cephalopods may mediate the co-option of the limb patterning program. Thus, our study suggests that this program could perform a more universal developmental function in radial patterning and highlights how canonical genetic programs are repurposed in novel structures.

Indexed as

CephalopodaAnimalsDrosophilaExtremitiesEyeGene Expression Regulation, DevelopmentalOrganogenesisCephalopodDlxEyeEye evolution, LensLimb patterningSpiraliaVisionWnt

Identifiers

PMID34983491
PMCPMC8728989
OpenAlexW4205883140

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.