Evidence map›Paper›PMID 34983419›Full record

ArticleBMC infectious diseases2022

Streptococcus agalactiae infective endocarditis in Canada: a multicenter retrospective nested case control analysis.

Torrance Oravec, S Annie Oravec, Jennifer Leigh, Liam Matthews, Bahareh Ghadaki, Dominik Mertz, Peter Daley, Anjali Shroff

Open access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC infectious diseases, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Descriptive review: global spectrum of invasive group B streptococcal disease in nonpregnant adults: epidemiology, risk factors and clinical presentations.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Review
  2. Bacteraemia with Streptococcus agalactiae - an observational study on clinical aspects and time to blood culture positivity.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026
    Observational
  3. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 1 country.

Torrance OravecDivision of Infectious Diseases, Department of Medicine, University of British Columbia, 328C Heather Pavilion E, 2733 Heather St. Vancouver, Vancouver, BC, V5Z 3J5, Canada. torrance.oravec@medportal.ca.
S Annie OravecDivision of Respirology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada.
Jennifer LeighDivision of Internal Medicine, Department of Medicine, University of Ottawa, Ottawa, ON, Canada.
Liam MatthewsDivision of Internal Medicine, Department of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
Bahareh GhadakiDivision of Infectious Diseases, Department of Medicine, Halton Healthcare, Oakville, ON, Canada.
Dominik MertzDivision of Infectious Diseases, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Peter DaleyDivision of Infectious Diseases, Department of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
Anjali ShroffDivision of Infectious Diseases, Department of Medicine, McMaster University, Hamilton, ON, Canada.
McMaster University · CAMemorial University of Newfoundland · CAUniversity of British Columbia · CAHalTech · CAUniversity of Ottawa · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundInfective endocarditis (IE) caused by Streptococcus agalactiae (GBS) is increasingly reported and associated with an aggressive course and high mortality rate. Existing literature on GBS IE is limited to case series; we compared the characteristics of patients with GBS IE to patients with GBS bacteremia without IE to identify risk factors for development of IE.

methodsA nested case-control study in a cohort of adult patients with GBS bacteremia over a 18-year period was conducted across seven centres in three Canadian cities. A chart review identified patients with possible or definite IE (per Modified Duke Criteria) and patients with IE were matched to those without endocarditis in a 1:3 fashion. Multivariate analyses were completed using logistic regression.

resultsOf 520 patients with GBS bacteremia, 28 cases of possible or definite IE were identified (5.4%). 68% (19/28) met criteria for definite IE, surgery was performed in 29% (8/28), and the overall in-hospital mortality rate was 29% (8/28). Multivariate analysis demonstrated that IE was associated with injection drug use (OR = 19.6, 95% CI = 3.39-111.11, p = 0.001), prosthetic valve (OR = 11.5, 95% CI = 1.73-76.92, p = 0.011) and lack of identified source of bacteremia (OR = 3.81, 95% CI = 1.24-11.65, p = 0.019).

conclusionsGBS bacteremia, especially amongst people who inject drugs, those with prosthetic valves, and those with no apparent source of infection, should increase clinical suspicion for IE.

Indexed as

EndocarditisEndocarditis, BacterialAdultCanadaCase-Control StudiesHumansRetrospective StudiesStreptococcus agalactiaeCase controlGroup B StreptococcusInfective endocarditisRetrospectiveStreptococcus agalactiae

Identifiers

PMID34983419
PMCPMC8725325
OpenAlexW4205299734

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.