ArticleBMC genomic data2022
Transcriptome analysis to identify the downstream genes of androgen receptor in dermal papilla cells.
Article in BMC genomic data, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Factors Associated with the Severity of Female Pattern Hair Loss: A Retrospective Study.Aesthetic plastic surgery · 2026Article
- Application of multi-omics techniques to androgenetic alopecia: Current status and perspectives.Computational and structural biotechnology journal · 2024Review
- Comprehensive transcriptome data to identify downstream genes of testosterone signalling in dermal papilla cells.Scientific data · 2022Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTestosterone signaling mediates various diseases, such as androgenetic alopecia and prostate cancer. Testosterone signaling is mediated by the androgen receptor (AR). In this study, we fortuitously found that primary and immortalized dermal papilla cells suppressed AR expression, although dermal papilla cells express AR in vivo. To analyze the AR signaling pathway, we exogenously introduced the AR gene via a retrovirus into immortalized dermal papilla cells and comprehensively compared their expression profiles with and without AR expression.
resultsWhole-transcriptome profiling revealed that the focal adhesion pathway was mainly affected by the activation of AR signaling. In particular, we found that caveolin-1 gene expression was downregulated in AR-expressing cells, suggesting that caveolin-1 is controlled by AR.
conclusionOur whole transcriptome data is critical resources for discovery of new therapeutic targets for testosterone-related diseases.
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