ArticleStroke2022
Sex Differences in Plaque Composition and Morphology Among Symptomatic Patients With Mild-to-Moderate Carotid Artery Stenosis.
Article in Stroke, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01208025 (The Assessment of the Plaque at RISK by Non-invasive), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Assessment of the Plaque at RISK by Non-invasive (Molecular) Imaging and Modelling (ParisK): Prospective Clinical Study for Diagnosis Efficacy for High Risk Plaque and Stroke.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Pooled it
- Multi-omics analysis of the gut microbiome and carotid artery atherosclerosis in men with and without HIV.EBioMedicine · 2026Article
- Prognostic value of plaque burden on computed tomography angiography in patients with symptomatic carotid artery disease.European stroke journal · 2026Article
- Sex differences in patients with symptomatic carotid stenosis included in three observational cohorts.European stroke journal · 2026Observational
- Sex-specific machine learning models for carotid plaque prediction in individuals with fatty liver disease: a cross-sectional study.BMJ open · 2026Article
- Regressing calcifications in the carotid artery: What's going on? A case series.Radiology case reports · 2025Article
- Development and validation of a machine learning model for predicting vulnerable carotid plaques using routine blood biomarkers and derived indicators: insights into sex-related risk patterns.Cardiovascular diabetology · 2025Article
- Carotid artery segmentation in computed tomography angiography (CTA) using multi-scale deep supervision with Swin-UNet and advanced data augmentation.Quantitative imaging in medicine and surgery · 2025Article
- Prevalence and associated risk factors of carotid plaque and artery stenosis in China: a population-based study.Frontiers of medicine · 2025Article
- Biomechanical assessment of vulnerable plaque: from histological evidence to ultrasound elastography and image-based computational patient-specific modelling.Frontiers in bioengineering and biotechnology · 2025Article
- Sex differences in features of atherosclerotic plaques as revealed by various imaging techniques: historical review.Frontiers in physiology · 2025Review
- Analysis of risk factors for carotid artery plaque in asymptomatic adults.BMC cardiovascular disorders · 2024Article
- Service delivery in acute ischemic stroke patients: Does sex matter?European journal of neurology · 2024Article
- Article
- Unravelling the role of carotid atherosclerosis in predicting cardiovascular disease risk: A review.ARYA atherosclerosis · 2024Review
- Age-dependent sex differences in non-stenotic intracranial plaque of embolic stroke of undetermined source.Scientific reports · 2023Article
- Magnetically assisted soft milli-tools for occluded lumen morphology detection.Science advances · 2023Article
- Biliverdin Reductase B Is a Plasma Biomarker for Intraplaque Hemorrhage and a Predictor of Ischemic Stroke in Patients with Symptomatic Carotid Atherosclerosis.Biomolecules · 2023Article
- Higher Leukocyte Count Is Associated with Lower Presence of Carotid Lipid-Rich Necrotic Core: A Sub-Study in the Plaque at RISK (PARISK) Study.Journal of clinical medicine · 2023Article
- Sex Differences in Subclinical Atherosclerosis and Systemic Immune Activation/Inflammation Among People With Human Immunodeficiency Virus in the United States.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023 · on this mapArticle
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeIncidence of ischemic stroke differs between men and women, with substantially higher rates in men. The underlying mechanism of this difference remains poorly understood but may be because of differences in carotid atherosclerosis. Using an in-depth imaging-based approach, we investigated differences between carotid plaque composition and morphology in male and female patients with stroke, taking into account differences in total plaque burden. Additionally, we investigated all possible within-artery combinations of plaque characteristics to explore differences between various plaque phenotypes.
methodsWe included 156 men and 68 women from the PARISK (Plaque At Risk) study, a prospective cohort study of patients with recent ischemic cerebrovascular symptoms and <70% ipsilateral carotid stenosis. Plaque characteristics (intraplaque hemorrhage [IPH], lipid-rich necrotic core [LRNC], calcifications, thin-or-ruptured fibrous cap, ulcerations, total plaque volume) were assessed with magnetic resonance imaging and multidetector-row computed tomography angiography. We used multivariable logistic and linear regression analyses to assess sex differences in plaque characteristics.
resultsWe found significant difference in total plaque volume between men and women (β=22.9 mm
conclusionsIn symptomatic patients with mild-to-moderate carotid stenosis, men are more likely to have a high-risk carotid plaque with IPH and LRNC than women, regardless of total plaque burden. Men also have more often a plaque with multiple vulnerable plaque components, which could comprise an even higher stroke risk. Registration: URL: https://www.clinicaltrials.gov; Unique identifier: NCT01208025.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.