ReviewBiological reviews of the Cambridge Philosophical Society2022
Improving zebrafish laboratory welfare and scientific research through understanding their natural history.
Review in Biological reviews of the Cambridge Philosophical Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The effect of laboratory diet and feeding on growth parameters in juvenile zebrafish.Lab animal · 2024Pooled it
- Pooled it
- Potential and challenges of Positron Emission Tomography beyond conventional preclinical and clinical imaging.Zeitschrift fur medizinische Physik · 2026Review
- Differential captivity and experiential conditions and its impact on the behaviour and cognition of Picasso triggerfish (Rhinecanthus aculeatus).Animal cognition · 2026Article
- Article
- Melissa officinalis essential oil modulates oxidative balance, cholinergic activity, and cognitive performance in a scopolamine-induced zebrafish model: implications for neuroprotective strategies in cognitive disorders.Scientific reports · 2025Article
- Critical insights into the potential risks of antipsychotic drugs to fish, including through effects on behaviour.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Zebrafish in the spotlight: expanding Frontiers in toxicology and drug discovery.Toxicology research · 2025Review
- Paradise fish (Macropodus opercularis) as a complementary translational model for emotional and cognitive function.Communications biology · 2025Article
- Zebrafish as a Model Organism for Post-Traumatic Stress Disorder: Insights into Stress Mechanisms and Behavioral Assays.Biology · 2025Review
- Advancing Zebrafish (Veterinary sciences · 2025Review
- The importance of understanding the ethology and ecology of the zebrafish, and of other fish species, in experimental research.Biologia futura · 2025Review
- Survival Strategies and Color Preferences of Mandarin Fish (Animals : an open access journal from MDPI · 2025Article
- Cognitive Bias in Adult Zebrafish (Veterinary sciences · 2025Review
- Rearing in a Physically Enriched Environment Affects Shoaling and Stress Responses of Zebrafish (Veterinary sciences · 2025Article
- Zebrafish (International journal of molecular sciences · 2024Review
- Zebrafish Models in Toxicology and Disease Studies.International journal of molecular sciences · 2024Article
- A survey of water chemistry used in zebrafish facilities and their effects on early zebrafish development.F1000Research · 2024Article
- Housing Conditions Affect Adult Zebrafish (Animals : an open access journal from MDPI · 2023Article
- Social behaviors as welfare indicators in teleost fish.Frontiers in veterinary science · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Globally, millions of zebrafish (Danio rerio) are used for scientific laboratory experiments for which researchers have a duty of care, with legal obligations to consider their welfare. Considering the growing use of the zebrafish as a vertebrate model for addressing a diverse range of scientific questions, optimising their laboratory conditions is of major importance for both welfare and improving scientific research. However, most guidelines for the care and breeding of zebrafish for research are concerned primarily with maximising production and minimising costs and pay little attention to the effects on welfare of the environments in which the fish are maintained, or how those conditions affect their scientific research. Here we review the physical and social conditions in which laboratory zebrafish are kept, identifying and drawing attention to factors likely to affect their welfare and experimental science. We also identify a fundamental lack knowledge of how zebrafish interact with many biotic and abiotic features in their natural environment to support ways to optimise zebrafish health and well-being in the laboratory, and in turn the quality of scientific data produced. We advocate that the conditions under which zebrafish are maintained need to become a more integral part of research and that we understand more fully how they influence experimental outcome and in turn interpretations of the data generated.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.