ArticleClinical infectious diseases : an official publication of the Infectious Diseases Society of America2022
Five-Year Mortality for Adults Entering Human Immunodeficiency Virus Care Under Universal Early Treatment Compared With the General US Population.
Article in Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Ten-Year Cost Projections for Medicare Beneficiaries 65 Years or Older With HIV.JAMA network open · 2026Article
- Impact of an HIV Care Coordination Program on All-cause, HIV-related, and Non-HIV-related Mortality in Younger and Older Adults With HIV in New York City, 2018-2022.Open forum infectious diseases · 2026Article
- Estimating Productivity Losses per HIV Infection due to Premature HIV Mortality in the United States.Medical decision making : an international journal of the Society for Medical Decision Making · 2026Article
- Impact of Comprehensive Strategy on Mortality in Heterosexually Transmitted HIV-Infected Individuals - Liangshan Prefecture, Sichuan Province, China, 2008-2024.China CDC weekly · 2025Article
- Social Engagement and Neurocognition in Latino and Non-Latino White Older Persons with HIV.AIDS and behavior · 2025Article
- Cancer screening in people living with HIV.Cancer medicine · 2023Review
- HIV and an Ageing Population-What Are the Medical, Psychosocial, and Palliative Care Challenges in Healthcare Provisions.Microorganisms · 2023Review
- HIV infection.Nature reviews. Disease primers · 2023Review
- A Growing Number of Men Who Have Sex With Men Aging With HIV (20212031): A Comparison of Two Microsimulation Models.The Journal of infectious diseases · 2023Article
- Cardiovascular Disease and Thrombosis in HIV Infection.Arteriosclerosis, thrombosis, and vascular biology · 2023Review
- Treatment Regimens and Care Models for Older Patients Living with HIV: Are We Doing Enough?HIV/AIDS (Auckland, N.Z.) · 2023Review
- Inequities in life course criminal legal system sanctions: measuring cumulative involvement.Annals of epidemiology · 2022Article
- Sex stratification of the trends and risk of mortality among individuals living with HIV under different transmission categories.Scientific reports · 2022Article
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Authors and funding
17 authors.
Funding
Abstract
backgroundMortality among adults with human immunodeficiency virus (HIV) remains elevated over those in the US general population, even in the years after entry into HIV care. We explore whether the elevation in 5-year mortality would have persisted if all adults with HIV had initiated antiretroviral therapy within 3 months of entering care.
methodsAmong 82 766 adults entering HIV care at North American AIDS Cohort Collaboration clinical sites in the United States, we computed mortality over 5 years since entry into HIV care under observed treatment patterns. We then used inverse probability weights to estimate mortality under universal early treatment. To compare mortality with those for similar individuals in the general population, we used National Center for Health Statistics data to construct a cohort representing the subset of the US population matched to study participants on key characteristics.
resultsFor the entire study period (1999-2017), the 5-year mortality among adults with HIV was 7.9% (95% confidence interval [CI]: 7.6%-8.2%) higher than expected based on the US general population. Under universal early treatment, the elevation in mortality for people with HIV would have been 7.2% (95% CI: 5.8%-8.6%). In the most recent calendar period examined (2011-2017), the elevation in mortality for people with HIV was 2.6% (95% CI: 2.0%-3.3%) under observed treatment patterns and 2.1% (.0%-4.2%) under universal early treatment.
conclusionsExpanding early treatment may modestly reduce, but not eliminate, the elevation in mortality for people with HIV.
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