ArticleNeuron2022
Make war not love: The neural substrate underlying a state-dependent switch in female social behavior.
Article in Neuron, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed.
- Hypothalamic prolactin receptorNature communications · 2026Article
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- The hormonal and neural control of maternal aggression.Current opinion in neurobiology · 2026Review
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- From identity to function: unveiling the cellular complexity of hypothalamic feeding circuits.Reviews in endocrine & metabolic disorders · 2026Review
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- Ventromedial hypothalamus (VMHvl) nNOS neurons regulate social behaviors in a sex-specific manner.Communications biology · 2025Article
- A line attractor maintains aggressiveness during feeding in "hangry" mice.bioRxiv : the preprint server for biology · 2025Article
- Maternal aggression driven by the transient mobilisation of a dormant hormone-sensitive circuit.Nature communications · 2025Article
- Brain circuits that regulate social behavior.Molecular psychiatry · 2025Review
- Estrogen Control of Social Behaviors.Annual review of neuroscience · 2025Review
- Article
- Suppression of hypothalamic oestrogenic signal sustains hyperprolactinemia and metabolic adaptation in lactating mice.Nature metabolism · 2025Article
- Article
- Article
- Altered thermal preference by preoptic estrogen receptor alpha neurons in postpartum females.Molecular metabolism · 2025Article
- Brain transcriptomics of a social challenge and maternal aggression in incubating female tree swallows.Hormones and behavior · 2025Article
- Control of tuberal hypothalamic development and its implications in metabolic disorders.Nature reviews. Endocrinology · 2025Review
- Hypothalamic Vasopressin Neurons Enable Maternal Thermoregulatory Behaviors.bioRxiv : the preprint server for biology · 2025Article
- The neurobiology of parenting and infant-evoked aggression.Physiological reviews · 2025Review
Corrections and comments
- Commented on bySocial switches.2022
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4 authors.
Funding
Abstract
Female mice exhibit opposing social behaviors toward males depending on their reproductive state: virgins display sexual receptivity (lordosis behavior), while lactating mothers attack. How a change in reproductive state produces a qualitative switch in behavioral response to the same conspecific stimulus is unknown. Using single-cell RNA-seq, we identify two distinct subtypes of estrogen receptor-1-positive neurons in the ventrolateral subdivision of the female ventromedial hypothalamus (VMHvl) and demonstrate that they causally control sexual receptivity and aggressiveness in virgins and lactating mothers, respectively. Between- and within-subject bulk-calcium recordings from each subtype reveal that aggression-specific cells acquire an increased responsiveness to social cues during the transition from virginity to maternity, while the responsiveness of the mating-specific population appears unchanged. These results demonstrate that reproductive-state-dependent changes in the relative activity of transcriptomically distinct neural subtypes can underlie categorical switches in behavior associated with physiological state changes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.