ArticlePloS one2022
The pathogenic biomarker alcohol dehydrogenase protein is involved in Bacillus cereus virulence and survival against host innate defence.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Genome-level insights into coordinated ethanol production and chaperone-driven stress tolerance in Bacillus cereus strain GRJBSBT-1 isolated from petroleum refinery sludge.Biotechnology for biofuels and bioproducts · 2026Article
- Genomic and phenotypic diversities among Bacillus cereus isolates from cosmetics.BMC microbiology · 2025Article
- Endogenous Ethanol Metabolism and Development of MASLD-MASH.International journal of molecular sciences · 2025Review
- Bacillus cereus is a key microbial determinant of intractable otitis media with effusion.Communications medicine · 2025Article
- Adherence and metal-ion acquisition gene expression increases during infection withInfection and immunity · 2024Article
- Genome-Wide Identification and Characterization of the Medium-Chain Dehydrogenase/Reductase Superfamily ofJournal of fungi (Basel, Switzerland) · 2024Article
- Genomic analysis and assessment of pathogenic (toxicogenic) potential of Staphylococcus haemolyticus and Bacillus paranthracis consortia isolated from bovine mastitis in Russia.Scientific reports · 2023Article
- Characterization of a Bacillus cereus strain associated with a large feed-related outbreak of severe infection in pigs.Journal of applied microbiology · 2022Article
- Identification of a New Pathogenicity Island Within the Large pAH187_270 Plasmid Involved inFrontiers in cellular and infection microbiology · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacillus cereus is a spore forming bacteria recognized among the leading agents responsible for foodborne outbreaks in Europe. B. cereus is also gaining notoriety as an opportunistic human pathogen inducing local and systemic infections. The real incidence of such infection is likely underestimated and information on genetic and phenotypic characteristics of the incriminated strains is generally scarce. We have recently analyzed a large strain collection of varying pathogenic potential. Screening for biomarkers to differentiate among clinical and non-clinical strains, a gene encoding an alcohol dehydrogenase-like protein was identified among the leading candidates. This family of proteins has been demonstrated to be involved in the virulence of several bacterial species. The relevant gene was knocked out to elucidate its function with regards to resistance to host innate immune response, both in vitro and in vivo. Our results demonstrate that the adhB gene plays a significant role in resistance to nitric oxide and oxidative stress in vitro, as well as its pathogenic ability with regards to in vivo toxicity. These properties may explain the pathogenic potential of strains carrying this newly identified virulence factor.
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Registered trials
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