Evidence map›Paper›PMID 34982591›Full record

ArticleAnnals of the Royal College of Surgeons of England2022

Hashimoto's thyroiditis on outcomes in papillary thyroid cancer revisited: experience from South East Asia.

J Lau, J Lee, M Mahipal, S P Yang, W B Tan, N K Yuan, R Parameswaran

Open access · greenAbstract read
In one paragraph

Article in Annals of the Royal College of Surgeons of England, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

J LauNational University Hospital, Singapore.
J LeeNational University Hospital, Singapore.
M MahipalNational University Hospital, Singapore.
S P YangNational University Hospital, Singapore.
W B TanNational University Hospital, Singapore.
N K YuanNational University Hospital, Singapore.
R ParameswaranNational University Hospital, Singapore.
National University Hospital · SGSingapore College of Traditional Chinese Medicine · SG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThe association between Hashimoto Thyroiditis (HT) and papillary thyroid cancer (PTC) remains uncertain. HT, the most common inflammatory condition of the thyroid, is postulated to increase the risk of PTC and yet confer cancer-retarding effects. In this study, we aim to evaluate the prevalence of HT in patients surgically treated for PTC and evaluate the long-term prognostic implications.

methodsThis is a retrospective study of 521 patients with PTC who underwent hemi- or total thyroidectomy between January 2000 and December 2018 at a tertiary referral centre. Patients were categorised into two group: group A (

resultsA total of 521 patients with a mean age of 46.7 years were evaluated. HT was detected in 22.8% of patients with PTC. On multivariate analysis, presence of HT was associated with a lower incidence of extrathyroidal extension (hazard ratio: 0.59, 95%confidence interval 0.37-0.95). Also, patients with HT tend to have fewer cycles of radioactive iodine and correspondingly have excellent response to treatment. However, no differences in recurrence rates and overall survival were detected.

conclusionsOne-fifth of patients with PTC have coexisting HT. These patients tend to have less-aggressive tumour features such as extrathyroidal extension. However, the effect of HT on recurrence and overall survival appears to be inconsequential clinically.

Indexed as

Carcinoma, PapillaryHashimoto DiseaseThyroid NeoplasmsAsia, EasternHumansIodine RadioisotopesMiddle AgedRetrospective StudiesThyroid Cancer, PapillaryIodine RadioisotopesCancerPapillaryThyroidThyroiditis

Identifiers

PMID34982591
PMCPMC9158069
OpenAlexW4206380745

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.