Evidence map›Paper›PMID 34982563›Full record

ArticleMolecular pharmaceutics2022

Targeting Amyloids with [

Chun Li, Pengxin Zhang, Ruirui Nie, Xiaoyan Gong, Jinghui Xie, Zilin Yu, Chengdong Wang, Hua Zhang, Ran Yan, Zhi Lu

Open access · hybridAbstract read
In one paragraph

Article in Molecular pharmaceutics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Thyroid Malignancy and Cutaneous Lichen Amyloidosis: Key Points AmidInternational journal of molecular sciences · 2024
    Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Chun LiDepartment of Nuclear Medicine, First Affiliated Hospital of Dalian Medical University, Liaoning 116021, People's Republic of China.
Pengxin ZhangDepartment of Pathology, First Affiliated Hospital of Dalian Medical University, Liaoning 116021, People's Republic of China.
Ruirui NieDepartment of Nuclear Medicine, First Affiliated Hospital of Dalian Medical University, Liaoning 116021, People's Republic of China.
Xiaoyan GongDepartment of Nuclear Medicine, First Affiliated Hospital of Dalian Medical University, Liaoning 116021, People's Republic of China.
Jinghui XieDepartment of Nuclear Medicine, First Affiliated Hospital of Dalian Medical University, Liaoning 116021, People's Republic of China.
Zilin YuSchool of Biomedical Engineering and Imaging Sciences, King's College London, St. Thomas' Hospital, London SE1 7EH, U.K.
Chengdong WangDepartment of Nuclear Medicine, First Affiliated Hospital of Dalian Medical University, Liaoning 116021, People's Republic of China.
Hua ZhangDepartment of Nuclear Medicine, First Affiliated Hospital of Dalian Medical University, Liaoning 116021, People's Republic of China.
Ran YanSchool of Biomedical Engineering and Imaging Sciences, King's College London, St. Thomas' Hospital, London SE1 7EH, U.K.ORCID 0000-0002-0303-3196
Zhi LuDepartment of Nuclear Medicine, First Affiliated Hospital of Dalian Medical University, Liaoning 116021, People's Republic of China.ORCID 0000-0003-1363-294X
Dalian Medical University · CNSt Thomas' Hospital · GB

Funding

Cancer Research UKDepartment of HealthMedical Research CouncilWellcome TrustWellcome Trust WT 203148/Z/16/Z
6 · The paper itself

Abstract

Medullary thyroid carcinoma (MTC) is a malignant neuroendocrine tumor with a high recurrence rate. Amyloid plaques formed from the misfolding of calcitonin are the key characteristics of MTC. Herein, we conducted a first-in-human pilot clinical study by applying a β-amyloid-specific radiotracer, [

Indexed as

Positron Emission Tomography Computed TomographyThyroid NeoplasmsFluorodeoxyglucose F18HumansNeoplasm Recurrence, LocalPositron-Emission TomographyFluorodeoxyglucose F18[18F]AV-45amyloidmedullary thyroid carcinomaPET/CT

Identifiers

PMID34982563
PMCPMC8826757
OpenAlexW4205286614

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.